Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-05-07 DOI:10.1016/j.cmet.2024.04.007

Qiang Cai, Yihao Tian, Quazi T.H. Shubhra

引用次数: 0

Abstract

Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase’s crucial role in regulating lipid metabolism in CD8⁺ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.

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以代谢回路为目标，增强 CD8+ T 细胞的抗肿瘤反应

肿瘤通过各种机制损害 T 细胞的功能，包括诱导营养稀缺的微环境，导致脂质积累和代谢重编程。Hunt 等人阐明了乙酰-CoA 羧化酶在调节 CD8+ T 细胞脂质代谢中的关键作用，发现了一种新的代谢策略来增强抗肿瘤免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.