The emerging role of tandem repeats in complex traits

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2024-05-07 DOI:10.1038/s41576-024-00736-8

Michael Lamkin, Melissa Gymrek

引用次数: 0

Abstract

Tandem repeats are a large source of genetic variation but are challenging to analyse and have been missing from most genome-wide studies. Results now suggest that systematic incorporation of tandem repeats into complex trait analyses is likely to yield a rich source of causal variants and new biological insights. In this Comment, Lamkin and Gymrek discuss recent results that suggest that the systematic incorporation of tandem repeats into complex trait analyses will yield a rich source of causal variants and new biological insights.

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串联重复序列在复杂性状中的新作用

串联重复序列是遗传变异的一大来源，但分析起来却很困难，而且大多数全基因组研究中都没有对其进行分析。现在的研究结果表明，将串联重复序列系统地纳入复杂性状分析可能会产生丰富的因果变异和新的生物学见解。在这篇评论中，Lamkin 和 Gymrek 讨论了最近的研究结果，这些结果表明，将串联重复序列系统地纳入复杂性状分析将产生丰富的因果变异和新的生物学见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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