Role of the intestinal microbiota in host defense against respiratory viral infections

IF 5.7 2区 医学 Q1 VIROLOGY
Idia Boncheva , Johanne Poudrier , Emilia L Falcone
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引用次数: 0

Abstract

Viral infections, including those affecting the respiratory tract, can alter the composition of the intestinal microbiota, which, in turn, can significantly influence both innate and adaptive immune responses, resulting in either enhanced pathogen clearance or exacerbation of the infection, possibly leading to inflammatory complications. A deeper understanding of the interplay between the intestinal microbiota and host immune responses in the context of respiratory viral infections (i.e. the gut–lung axis) is necessary to develop new treatments. This review highlights key mechanisms by which the intestinal microbiota, including its metabolites, can act locally or at distant organs to combat respiratory viruses. Therapeutics aimed at harnessing the microbiota to prevent and/or help treat respiratory viral infections represent a promising avenue for future investigation.

肠道微生物群在宿主防御呼吸道病毒感染中的作用
病毒感染(包括影响呼吸道的病毒感染)会改变肠道微生物群的组成,而肠道微生物群又会极大地影响先天性免疫反应和适应性免疫反应,导致病原体清除能力增强或感染加剧,并可能导致炎症并发症。要开发新的治疗方法,就必须深入了解呼吸道病毒感染中肠道微生物群与宿主免疫反应之间的相互作用(即肠道-肺轴)。本综述重点介绍了肠道微生物群(包括其代谢产物)在局部或远处器官对抗呼吸道病毒的关键机制。旨在利用微生物群预防和/或帮助治疗呼吸道病毒感染的疗法是未来研究的一个前景广阔的途径。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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