Validity of the DSM-5 Mixed Features Specifier Interview

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2024-04-29 DOI:10.1111/bdi.13436

Mark Zimmerman, Daniel Mackin

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引用次数: 0

Abstract

Objectives

To examine the reliability and validity of a semi-structured interview assessing the features of the DSM-5 mixed features specifier. Our goal was to develop an instrument that could be used for both diagnostic and severity measurement purposes.

Methods

Four hundred fifty-nine psychiatric patients in a depressive episode were interviewed by a trained diagnostic rater who administered semi-structured interviews including the DSM-5 Mixed Features Specifier Interview (DMSI). We examined the inter-rater reliability and psychometric properties of the DMSI. The patients were rated on clinician rating scales of depression, anxiety, and irritability, and measures of psychosocial functioning, suicidality, and family history of bipolar disorder.

Results

The DMSI had excellent joint-interview interrater reliability. More than twice as many patients met the DSM-5 mixed features specifier criteria during the week before the assessment than for the majority of the episode (9.4% vs. 3.9%). DMSI total scores were more highly correlated with a clinician-rated measure of manic symptoms than with measures of depression and anxiety. More patients with bipolar depression met the mixed features specifier than patients with MDD. Amongst patients with MDD, those with mixed features more frequently had a family history of bipolar disorder, were more frequently diagnosed with anxiety disorders, attention deficit disorder, and borderline personality disorder, more frequently had attempted suicide, and were more severely depressed, anxious, and irritable.

Conclusion

The DMSI is a reliable and valid measure of the presence of the DSM-5 mixed features specifier in depressed patients as well as the severity of the features of the specifier.

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DSM-5 混合特征说明访谈的有效性

目的研究一种半结构化访谈的可靠性和有效性，以评估 DSM-5 中混合特征说明的特征。我们的目标是开发一种既可用于诊断又可用于严重程度测量的工具。方法459 名抑郁发作的精神病患者接受了一名训练有素的诊断评分员的访谈，该评分员进行了半结构化访谈，其中包括 DSM-5 混合特征分类器访谈（DMSI）。我们研究了 DMSI 的评分者间可靠性和心理测量特性。临床医生对患者的抑郁、焦虑和易怒程度进行了评分，并对心理社会功能、自杀倾向和双相情感障碍家族史进行了测量。在评估前一周符合DSM-5混合特征指定标准的患者人数是大部分发作期的两倍多（9.4%对3.9%）。DMSI 总分与临床医生评定的躁狂症状相关性比与抑郁和焦虑相关性更高。与 MDD 患者相比，有更多的双相抑郁症患者符合混合特征指标。在 MDD 患者中，具有混合特征的患者更多有双相情感障碍家族史，更多被诊断为焦虑症、注意力缺陷障碍和边缘型人格障碍，更多尝试过自杀，抑郁、焦虑和易激惹的程度也更严重。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.