Stijn Voerman, Robin Broersen, Sigrid M. A. Swagemakers, Chris I. De Zeeuw, Peter J. van der Spek
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引用次数: 0
Abstract
Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.
尽管小脑皮质的外观千篇一律,但它在结构、遗传学和生理学方面却具有高度异质性。小脑皮质的主要和唯一输出神经元浦肯野细胞(PCs)可分为多个种群,这些种群可不同地表达分子标记并显示出独特的生理特征。这些特征包括动作电位率、突触倾向和内在可塑性。然而,与 PCs 不同生理特性相关的确切分子和遗传因素仍然难以捉摸。在本文中,我们将详细概述调控 PC 活性和可塑性的细胞机制。我们还进一步进行了通路分析,以强调特定 PC 群的分子特征可能如何影响其生理学和可塑性机制。
期刊介绍:
molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged
BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.