The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch

IF 7.5 2区医学 Q1 IMMUNOLOGY

Immunological Reviews Pub Date : 2024-04-29 DOI:10.1111/imr.13338

Qun Wang, Sean M. Hartig, Christie M. Ballantyne, Huaizhu Wu

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Abstract

White adipose tissue (WAT) is a vital endocrine organ that regulates energy balance and metabolic homeostasis. In addition to fat cells, WAT harbors macrophages with distinct phenotypes that play crucial roles in immunity and metabolism. Nutrient demands cause macrophages to accumulate in WAT niches, where they remodel the microenvironment and produce beneficial or detrimental effects on systemic metabolism. Given the abundance of macrophages in WAT, this review summarizes the heterogeneity of WAT macrophages in physiological and pathological conditions, including their alterations in quantity, phenotypes, characteristics, and functions during WAT growth and development, as well as healthy or unhealthy expansion. We will discuss the interactions of macrophages with other cell partners in WAT including adipose stem cells, adipocytes, and T cells in the context of various microenvironment niches in lean or obese condition. Finally, we highlight how adipose tissue macrophages merge immunity and metabolic changes to govern energy balance for the organism.

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白色脂肪组织中巨噬细胞的多面生活：免疫转变与新陈代谢转换的结合

摘要白色脂肪组织（WAT）是调节能量平衡和新陈代谢平衡的重要内分泌器官。除脂肪细胞外，白脂肪组织还蕴藏着表型各异的巨噬细胞，它们在免疫和新陈代谢中发挥着至关重要的作用。营养需求会导致巨噬细胞聚集在 WAT 壁龛中，并在那里重塑微环境，对全身代谢产生有益或有害的影响。鉴于巨噬细胞在 WAT 中的大量存在，本综述总结了 WAT 中巨噬细胞在生理和病理条件下的异质性，包括它们在 WAT 生长和发育过程中数量、表型、特征和功能的改变，以及健康或不健康的扩张。我们将讨论巨噬细胞与脂肪干细胞、脂肪细胞和 T 细胞等其他细胞伙伴在瘦或肥胖状态下的各种微环境龛位中的相互作用。最后，我们将重点介绍脂肪组织巨噬细胞如何将免疫和新陈代谢变化结合起来，从而控制机体的能量平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunological Reviews 医学-免疫学

CiteScore

16.20

自引率

1.10%

发文量

118

审稿时长

4-8 weeks

期刊介绍： Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.