An Efficient Synthesis of α‐Sulfonamide Phosphonates through Metal‐Free Three‐Component Reaction

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC
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引用次数: 0

Abstract

A metal‐free three‐component reaction for the direct synthesis of α‐sulfonamide phosphonates involving sulfonamide derivatives, benzaldehyde derivatives, and diethyl phosphite, has been achieved with high yields using ethanol as a green solvent. This efficient method reduces reaction time and minimizes the use of excess reagents. Hitherto, no reports have been found in the literature for the direct synthesis of α‐sulfonamide phosphonates from the readily available aldehydes, diethyl phosphite, and sulfonamides, emphasizing the novelty and significance of this work.

通过无金属三组分反应高效合成α-磺酰胺膦酸盐
以乙醇为绿色溶剂,利用磺酰胺衍生物、苯甲醛衍生物和亚磷酸二乙酯直接合成α-磺酰胺膦酸盐的无金属三组分反应实现了高产率。这种高效的方法缩短了反应时间,并最大限度地减少了过量试剂的使用。迄今为止,文献中还没有发现用现成的醛、亚磷酸二乙酯和磺酰胺直接合成α-磺酰胺膦酸盐的报道,这突出了这项工作的新颖性和重要性。
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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