Age-related enhancement of the association between episodic memory and gray matter volume in medial temporal and frontal lobes

IF 4.7 2区心理学 Q1 BEHAVIORAL SCIENCES

Behavioral and Brain Functions Pub Date : 2024-05-03 DOI:10.1186/s12993-024-00237-y

Shaokun Zhao, Feng Sang, Chen Liu, Fei Wang, Jiawen Liu, Chuansheng Chen, Jun Wang, Xin Li, Zhanjun Zhang

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Abstract

Episodic memory (EM) deteriorates as a result of normal aging as well as Alzheimer’s disease. The neural underpinnings of such age-related memory impairments in older individuals are not well-understood. Although previous research has unveiled the association between gray matter volume (GMV) and EM in the elderly population, such findings exhibit variances across distinct age cohorts. Consequently, an investigation into the dynamic evolution of this relationship with advancing age is imperative. The present study utilized a sliding window approach to examine how the correlation between EM and GMV varied with age in a cross-sectional sample of 926 Chinese older adults. We found that both verbal EM (VEM) and spatial EM (SEM) exhibited positive correlations with GMV in extensive areas primarily in the temporal and frontal lobes and that these correlations typically became stronger with older age. Moreover, there were variations in the strength of the correlation between EM and GMV with age, which differed based on sex and the specific type of EM. Specifically, the association between VEM and GMVs in the insula and parietal regions became stronger with age for females but not for males, whereas the association between SEM and GMVs in the parietal and occipital regions became stronger for males but not for females. At the brain system level, there is a significant age-related increase in the correlations between both types of EM and the GMV of both the anterior temporal (AT) system and the posterior medial (PM) system in male group. In females, both types of EM show stronger age-related correlations with the GMV of the AT system compared to males. Our study revealed a significant positive correlation between GMV in most regions associated with EM and age, particularly in the frontal and temporal lobes. This discovery offers new insights into the connection between brain structure and the diminishing episodic memory function among older individuals.

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与年龄有关的颞叶内侧和额叶记忆力与灰质体积之间联系的增强

外显记忆（EM）会随着正常衰老和阿尔茨海默病的发生而退化。目前还不十分清楚老年人这种与年龄相关的记忆障碍的神经基础。尽管之前的研究揭示了老年人群灰质体积（GMV）与记忆力之间的关系，但这些研究结果在不同年龄段的人群中表现出差异。因此，研究这种关系随着年龄增长的动态演变势在必行。本研究采用滑动窗口法，在 926 位中国老年人的横断面样本中研究了 EM 与 GMV 之间的相关性如何随年龄而变化。我们发现，在主要位于颞叶和额叶的广泛区域，言语 EM（VEM）和空间 EM（SEM）均与 GMV 呈正相关，而且这些相关性通常随着年龄的增长而增强。此外，EM 与 GMV 之间的相关性强度随年龄的增长而变化，并因性别和 EM 的具体类型而异。具体来说，随着年龄的增长，女性的脑岛和顶叶区的VEM与GMV之间的相关性变得更强，而男性则不然；而男性的顶叶和枕叶区的SEM与GMV之间的相关性变得更强，女性则不然。在大脑系统水平上，男性组的两种 EM 与颞叶前部（AT）系统和内侧后部（PM）系统的 GMV 之间的相关性都随着年龄的增长而显著增加。与男性相比，女性两种EM与AT系统GMV的年龄相关性更强。我们的研究发现，与EM相关的大多数区域的GMV与年龄之间存在明显的正相关，尤其是在额叶和颞叶。这一发现为我们了解大脑结构与老年人记忆功能减退之间的联系提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioral and Brain Functions 医学-行为科学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.