Measurement of proviral load associated with the development of lymphocytosis in bovine leukaemia virus‐infected Holstein cattle at a dairy farm in Japan

IF 0.3 Q4 VETERINARY SCIENCES

Veterinary Record Case Reports Pub Date : 2024-04-30 DOI:10.1002/vrc2.883

Kenichiro Kobayashi

引用次数: 0

Abstract

We monitored the bovine leukaemia virus (BLV) proviral load (PVL) in peripheral blood lymphocytes (PBLs) and the PBL counts in BLV‐infected cattle on a dairy farm in Japan to determine the changes in PVL with the progression of lymphocytosis. A total of 25 BLV‐infected Holstein cattle at a dairy farm were followed up from May 2015 (0 month) to April 2016 (11 months). PBL counts and PVL were measured three times in 25 cattle. Based on their PBL counts, five cattle with normal PBL (≤7500 cells/µL) at 0 month but high PBL (>7500 cells/µL) at 11 months were classified as the increased group. All cattle in the increased group showed increased PVL compared to asymptomatic aleukaemic carriers at 11 months. This study revealed increases in PVL with the progression of lymphocytosis, suggesting that cattle with progression of lymphocytosis should be segregated from BLV‐negative cattle as soon as possible.

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测定日本一家奶牛场中受牛白血病病毒感染的荷斯坦牛发生淋巴细胞增多症时的病毒载量

我们监测了日本一家奶牛场受BLV感染的牛的外周血淋巴细胞（PBL）中的牛白血病病毒（BLV）前病毒载量（PVL）和PBL计数，以确定随着淋巴细胞增多，PVL的变化情况。从2015年5月（0个月）到2016年4月（11个月），对一家奶牛场的25头BLV感染的荷斯坦牛进行了随访。对 25 头牛的 PBL 计数和 PVL 进行了三次测量。根据PBL计数，5头牛在0个月时PBL正常（≤7500个细胞/μL），但在11个月时PBL较高（7500个细胞/μL），这5头牛被归为增高组。与 11 个月时无症状的白血病携带者相比，增高组的所有牛的 PVL 都有所增高。这项研究表明，随着淋巴细胞增多症的发展，PVL 也会增加，这表明淋巴细胞增多症发展的牛应尽快与 BLV 阴性牛隔离。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Record Case Reports Veterinary-Veterinary (all)

CiteScore

0.50

自引率

33.30%

发文量

266

期刊介绍： Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.