Diagnosis and treatment of metastatic uterine lymphoma in a chinchilla (Chinchilla lanigera)

IF 0.3 Q4 VETERINARY SCIENCES

Veterinary Record Case Reports Pub Date : 2024-05-03 DOI:10.1002/vrc2.886

Alicia McLaughlin, Chelsea Tripp, Eric Hostnik, Anna‐Maria Travis, Elise LaDouceur

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引用次数: 0

Abstract

A 4‐year‐old, entire, female chinchilla (Chinchilla lanigera) presented to an emergency veterinary hospital for laboured breathing, lethargy and hyporexia. Physical exam findings and diagnostic imaging were supportive of uterine disease. An ovariohysterectomy was performed, and histopathology diagnosed incompletely resected uterine lymphoma. A rotating outpatient chemotherapy protocol containing oral prednisolone (0.5 mg/kg), subcutaneous L‐asparaginase (400 iu/kg), oral cyclophosphamide (200 mg/m2) and subcutaneous cytosine arabinoside (50 mg/kg) was initiated. The patient tolerated chemotherapeutics well based on normal behaviour, appetite, exam findings and serial bloodwork values. One hundred two days after initial presentation, the patient was euthanased due to a decline in clinical condition. Postmortem examination and histopathology confirmed metastasis of lymphoma to the brain, mediastinum, mesentery, liver and spleen. No evidence of organ damage due to chemotherapeutics was noted histologically. Postmortem immunohistochemistry confirmed the diagnosis of lymphoma. Further studies are needed to guide chemotherapeutic dosing and treatment of lymphoma in chinchillas.

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龙猫（Chinchilla lanigera）转移性子宫淋巴瘤的诊断和治疗

一只 4 岁大的整只雌性龙猫（Chinchilla lanigera）因呼吸困难、嗜睡和厌食症前往一家急诊兽医院就诊。体格检查结果和影像诊断结果均支持子宫疾病。医生为它进行了卵巢切除术，组织病理学诊断为未完全切除的子宫淋巴瘤。患者开始接受门诊轮换化疗方案，包括口服泼尼松龙（0.5 mg/kg）、皮下注射L-天冬酰胺酶（400 iu/kg）、口服环磷酰胺（200 mg/m2）和皮下注射阿糖胞苷（50 mg/kg）。患者的行为、食欲、检查结果和连续血检值均正常，化疗耐受性良好。初次发病 120 天后，患者因临床状况恶化而被安乐死。尸检和组织病理学证实淋巴瘤转移到了大脑、纵隔、肠系膜、肝脏和脾脏。组织病理学上没有发现化疗导致器官损伤的证据。死后免疫组化证实了淋巴瘤的诊断。要指导龙猫淋巴瘤的化疗剂量和治疗，还需要进一步的研究。

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来源期刊

Veterinary Record Case Reports Veterinary-Veterinary (all)

CiteScore

0.50

自引率

33.30%

发文量

266

期刊介绍： Vet Record Case Reports is an online resource that publishes articles in all fields of veterinary medicine and surgery so that veterinary professionals, researchers and others can easily find important information on both common and rare conditions. Articles may be about a single animal, herd, flock or other group of animals managed together. Common cases that present a diagnostic, ethical or management challenge, or that highlight aspects of mechanisms of injury, pharmacology or histopathology are deemed of particular educational value. All articles are peer reviewed and copy edited before publication.