Research progress on the mechanism of acute hypertriglyceridemic pancreatitis.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Pancreas Pub Date : 2024-05-01 DOI:10.1097/mpa.0000000000002364

Yiteng Meng, Peiyu Han, Xiaoyu Ma, Yiting He, Hetian Chen, Hongbo Ren

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Abstract

The incidence rate of hypertriglyceridemia pancreatitis (HTGP) has experienced a notable increase in recent years, with eclipsing alcohol as the second leading cause of acute pancreatitis (AP). HTGP is often associated with more severe local and systemic complications. Recognized as a metabolic disorder hypertriglyceridemia (HTG), holds significant relevance in the pathogenesis of HTGP, yet its mechanisms are not fully understood. Both primary (genetic) and secondary (acquired) factors contribute to elevated triglyceride (TG) levels, which concurrently influence the progression of HTGP. This article presents a comprehensive review of the evolving research on HTGP pathogenesis, encompassing lipid synthesis and metabolism, calcium signal transduction, inflammatory mediators, endoplasmic reticulum stress, autophagy, mitochondrial injury by fatty acids, oxidative stress response, genetic factors, and gene mutations. By unraveling the intricate mechanisms underlying HTGP, this article aims to enhance physicians' understanding of the disease and facilitate the development of potential targeted pharmacological interventions for patients.

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急性高甘油三酯性胰腺炎机制的研究进展。

近年来，高甘油三酯血症胰腺炎（HTGP）的发病率明显上升，已超过酒精成为急性胰腺炎（AP）的第二大病因。高甘油三酯血症胰腺炎通常伴有更严重的局部和全身并发症。高甘油三酯血症（HTG）被认为是一种代谢性疾病，与急性胰腺炎的发病机制密切相关，但其发病机制尚未完全明了。原发性（遗传）和继发性（获得性）因素都会导致甘油三酯（TG）水平升高，同时影响 HTGP 的进展。本文全面回顾了有关 HTGP 发病机制的研究进展，包括脂质合成和代谢、钙信号转导、炎症介质、内质网应激、自噬、脂肪酸对线粒体的损伤、氧化应激反应、遗传因素和基因突变。通过揭示 HTGP 的复杂机制，本文旨在提高医生对该疾病的认识，并促进为患者开发潜在的靶向药物干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pancreas 医学-胃肠肝病学

CiteScore

4.70

自引率

3.40%

发文量

289

审稿时长

1 months

期刊介绍： Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.