The immune interactions of gut glycans and microbiota in health and disease

IF 2.6 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Microbiology Pub Date : 2024-05-04 DOI:10.1111/mmi.15267

Mahmut Demirturk, Mukaddes Sena Cinar, Fikri Y. Avci

引用次数: 0

Abstract

The human digestive system harbors a vast diversity of commensal bacteria and maintains a symbiotic relationship with them. However, imbalances in the gut microbiota accompany various diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancers (CRCs), which significantly impact the well‐being of populations globally. Glycosylation of the mucus layer is a crucial factor that plays a critical role in maintaining the homeostatic environment in the gut. This review delves into how the gut microbiota, immune cells, and gut mucus layer work together to establish a balanced gut environment. Specifically, the role of glycosylation in regulating immune cell responses and mucus metabolism in this process is examined.

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肠道糖和微生物群在健康和疾病中的免疫相互作用

人类的消化系统蕴藏着种类繁多的共生细菌，并与它们保持着共生关系。然而，肠道微生物群的失衡伴随着各种疾病，如炎症性肠病（IBD）和结肠直肠癌（CRC），严重影响着全球人口的健康。粘液层的糖基化是一个关键因素，在维持肠道内的平衡环境方面起着至关重要的作用。本综述深入探讨了肠道微生物群、免疫细胞和肠道粘液层如何共同建立平衡的肠道环境。具体来说，本文将研究糖基化在调节免疫细胞反应和粘液代谢过程中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Microbiology 生物-生化与分子生物学

CiteScore

7.20

自引率

5.60%

发文量

132

审稿时长

1.7 months

期刊介绍： Molecular Microbiology, the leading primary journal in the microbial sciences, publishes molecular studies of Bacteria, Archaea, eukaryotic microorganisms, and their viruses. Research papers should lead to a deeper understanding of the molecular principles underlying basic physiological processes or mechanisms. Appropriate topics include gene expression and regulation, pathogenicity and virulence, physiology and metabolism, synthesis of macromolecules (proteins, nucleic acids, lipids, polysaccharides, etc), cell biology and subcellular organization, membrane biogenesis and function, traffic and transport, cell-cell communication and signalling pathways, evolution and gene transfer. Articles focused on host responses (cellular or immunological) to pathogens or on microbial ecology should be directed to our sister journals Cellular Microbiology and Environmental Microbiology, respectively.