Interhemispheric coherence of EEG rhythms in children: Maturation and differentiation in corpus callosum dysgenesis

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2024-05-01 DOI:10.1016/j.neucli.2024.102981

J. Guillou , J. Duprez , R. Nabbout , A. Kaminska , S. Napuri , C. Gomes , M. Kuchenbuch , P. Sauleau

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引用次数: 0

Abstract

Objectives

To evaluate the evolution of interhemispheric coherences (ICo) in background and spindle frequency bands during childhood and use it to identify individuals with corpus callosum dysgenesis (CCd).

Methods

A monocentric cohort of children aged from 0.25 to 15 years old, consisting of 13 children with CCd and 164 without, was analyzed. The ICo of background activity (ICO_BckgrdA), sleep spindles (ICO_spindles), and their sum (_sICO) were calculated. The impact of age, gender, and CC status on the ICo was evaluated, and the _sICO was used to discriminate children with or without CCd.

Results

ICO_BckgrdA, ICO_spindles and sICO increased significantly with age without any effect of gender (p < 10⁻⁴), in both groups. The regression equations of the different ICo were stronger, with adjusted R2 values of 0.54, 0.35, and 0.57, respectively. The ICo was lower in children with CCd compared to those without CCd (p < 10⁻⁴ for all comparisons). The area under the precision recall curves for predicting CCd using _sICO was 0.992 with 98.9 % sensitivity and 87.5 % specificity.

Discussion

ICo of spindles and background activity evolve in parallel to brain maturation and depends on the integrity of the corpus callosum. sICO could be an effective diagnostic biomarker for screening children with interhemispheric dysfunction.

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儿童脑电图节律的半球间一致性：胼胝体发育不良的成熟和分化

目的评估儿童期背景频带和主轴频带的半球间一致性（ICo）的演变，并利用它来识别胼胝体发育不良（CCd）的个体。方法分析年龄在 0.25 到 15 岁之间的单中心队列儿童，其中包括 13 名患有 CCd 的儿童和 164 名未患有 CCd 的儿童。计算了背景活动 ICo（ICOBckgrdA）、睡眠棘波（ICOspindles）及其总和（sICO）。结果ICOBckgrdA、ICOspindles和sICO随着年龄的增长而显著增加，但在两组中均不受性别影响（p <10-4）。不同 ICo 的回归方程更强，调整后的 R2 值分别为 0.54、0.35 和 0.57。与无 CCd 的儿童相比，有 CCd 的儿童的 ICo 更低（所有比较的 p < 10-4）。使用 sICO 预测 CCd 的精确召回曲线下面积为 0.992，灵敏度为 98.9%，特异度为 87.5%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.