Modelling the dynamics of microbubble undergoing stable and inertial cavitation: Delineating the effects of ultrasound and microbubble parameters on sonothrombolysis

IF 5.3 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Zhi Qi Tan , Ean Hin Ooi , Yeong Shiong Chiew , Ji Jinn Foo , Yin Kwee Ng , Ean Tat Ooi
{"title":"Modelling the dynamics of microbubble undergoing stable and inertial cavitation: Delineating the effects of ultrasound and microbubble parameters on sonothrombolysis","authors":"Zhi Qi Tan ,&nbsp;Ean Hin Ooi ,&nbsp;Yeong Shiong Chiew ,&nbsp;Ji Jinn Foo ,&nbsp;Yin Kwee Ng ,&nbsp;Ean Tat Ooi","doi":"10.1016/j.bbe.2024.04.003","DOIUrl":null,"url":null,"abstract":"<div><p>Sonothrombolysis induces clot breakdown using ultrasound waves to excite microbubbles. Despite the great potential, selecting optimal ultrasound (frequency and pressure) and microbubble (radius) parameters remains a challenge. To address this, a computational model was developed to investigate the bubble behaviour during sonothrombolysis. The blood and clot were assumed to be non-Newtonian and porous, respectively. The effects of ultrasound and microbubble parameters on flow-induced shear stress on the clot surface during stable and inertial cavitation were investigated. It was found that microbubble translation towards the clot and the shear stress on the clot surface during stable cavitation were significant when the bubble was about to undergo inertial cavitation. While insonation of large microbubble (radius of <span><math><mrow><mn>1</mn><mo>.</mo><mn>65</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span>) at low frequency (0.50 MHz) produced the highest shear stress during stable cavitation, selection of these parameters is not as intuitive for inertial cavitation due to the strong competing effect between jet velocity and translational distance. An increase in jet velocity is always accompanied by a decrease in the translational distance and vice versa. Therefore, a right balance between the jet velocity and the translational distance is critical to maximise the shear stress on the clot surface. A jet velocity of 303 m/s and a distance travelled of <span><math><mrow><mn>5</mn><mo>.</mo><mn>12</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span> at an initial bubble-clot separation of <span><math><mrow><mn>10</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span> produced the greatest clot surface shear stress. This is achievable by insonating a <span><math><mrow><mn>0</mn><mo>.</mo><mn>55</mn><mspace></mspace><mi>μ</mi><mi>m</mi></mrow></math></span> microbubble using 0.50 MHz and 600 kPa ultrasound.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 2","pages":"Pages 358-368"},"PeriodicalIF":5.3000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000275/pdfft?md5=3e30ca360dcd5e3cc5a1a52cc4cf81df&pid=1-s2.0-S0208521624000275-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocybernetics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0208521624000275","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Sonothrombolysis induces clot breakdown using ultrasound waves to excite microbubbles. Despite the great potential, selecting optimal ultrasound (frequency and pressure) and microbubble (radius) parameters remains a challenge. To address this, a computational model was developed to investigate the bubble behaviour during sonothrombolysis. The blood and clot were assumed to be non-Newtonian and porous, respectively. The effects of ultrasound and microbubble parameters on flow-induced shear stress on the clot surface during stable and inertial cavitation were investigated. It was found that microbubble translation towards the clot and the shear stress on the clot surface during stable cavitation were significant when the bubble was about to undergo inertial cavitation. While insonation of large microbubble (radius of 1.65μm) at low frequency (0.50 MHz) produced the highest shear stress during stable cavitation, selection of these parameters is not as intuitive for inertial cavitation due to the strong competing effect between jet velocity and translational distance. An increase in jet velocity is always accompanied by a decrease in the translational distance and vice versa. Therefore, a right balance between the jet velocity and the translational distance is critical to maximise the shear stress on the clot surface. A jet velocity of 303 m/s and a distance travelled of 5.12μm at an initial bubble-clot separation of 10μm produced the greatest clot surface shear stress. This is achievable by insonating a 0.55μm microbubble using 0.50 MHz and 600 kPa ultrasound.

建立稳定和惯性空化微泡动力学模型:划定超声和微泡参数对超声溶栓的影响
超声溶栓是利用超声波激发微泡诱导血栓破裂。尽管潜力巨大,但选择最佳超声波(频率和压力)和微泡(半径)参数仍是一项挑战。为了解决这个问题,我们开发了一个计算模型来研究声波溶栓过程中的气泡行为。假设血液和血块分别为非牛顿和多孔。研究了稳定空化和惯性空化过程中超声和微泡参数对血块表面流动引起的剪应力的影响。研究发现,当气泡即将发生惯性空化时,微泡向凝块的平移和稳定空化过程中凝块表面的剪切应力非常显著。虽然在低频(0.50 MHz)下对大微气泡(半径为 1.65μm)进行电离能在稳定空化过程中产生最高的剪应力,但由于射流速度和平移距离之间存在强烈的竞争效应,在惯性空化过程中这些参数的选择并不那么直观。射流速度的增加总是伴随着平移距离的减小,反之亦然。因此,射流速度和平移距离之间的适当平衡对于最大限度地提高凝块表面的剪应力至关重要。在初始气泡-血块分离度为 10μm 时,303 m/s 的射流速度和 5.12μm 的移动距离产生了最大的血块表面剪切应力。使用 0.50 MHz 和 600 kPa 超声波对 0.55μm 的微气泡进行电离可达到这一效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
16.50
自引率
6.20%
发文量
77
审稿时长
38 days
期刊介绍: Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信