Association of hemoglobin-to-red blood cell distribution width ratio and cognition: A cross-sectional study

Archives of Gerontology and Geriatrics Plus Pub Date : 2024-04-26 DOI:10.1016/j.aggp.2024.100027

Yan Zhang M.D. , Fang Fang M.D. , Lijuan Xi M.D. , Jiajie Zhou M.D. , Peirong Xu M.D. , Jiayuan Tu M.D.

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Abstract

Purpose

This study aimed to investigate the association between hemoglobin-to-red blood cell distribution width ratio (HRR) and cognitive function.

Methods

Data, including cognition assessment, general characteristics, lifestyle attributes, disease-related factors, and blood indicators, were extracted from older people from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 database. Statistical analysis included the Mann-Whitney U test, chi-square test, spearman correlation, and multiple linear regression.

Results

A total of 2452 participants were included, with 631(25.7 %) identified as having low-level cognition. HRR was significantly lower in the lower cognition group (P < 0.001) and positively associated with cognition score (P < 0.001). Multiple linear logistic regression analysis indicated that HRR remained associated with cognition even after adjusting for general characteristics, lifestyle attributes, disease-related factors, and blood indicators (P = 0.046).

Conclusion

Lower HRR is an independent risk factor for low cognitive performance in older adults. However, further investigation is needed to elucidate the precise mechanism underlying the impact of HRR on cognitive function.

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血红蛋白-红细胞分布宽度比与认知能力的关系：横断面研究

目的本研究旨在探讨血红蛋白与红细胞分布宽度比（HRR）与认知功能之间的关系。方法从美国国家健康与营养调查（NHANES）2011-2014年数据库中提取老年人的数据，包括认知评估、一般特征、生活方式属性、疾病相关因素和血液指标。统计分析包括曼-惠特尼 U 检验、卡方检验、矛曼相关和多元线性回归。低认知水平组的 HRR 明显较低（P < 0.001），且与认知水平得分呈正相关（P < 0.001）。多元线性逻辑回归分析表明，即使调整了一般特征、生活方式属性、疾病相关因素和血液指标，HRR 仍与认知能力相关（P = 0.046）。然而，要阐明 HRR 对认知功能影响的确切机制，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of Gerontology and Geriatrics Plus

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