Association between coffee and caffeine intake and risk of COPD: Findings based on NHANES 2007–2012

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-05-02 DOI:10.1016/j.hrtlng.2024.04.015

Wan-Zhe Liao , Jia-Xin Li , Wei-Yi Feng , Jia-Qi Xiao , Zi-Xun Wang , Shuo-Jia Xie , Yi-Ming Hu , Jun-Hao Mao , Ze-Min Huang , Xu-Guang Guo , Wei-Jie Guan

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引用次数: 0

Abstract

Background

The association between coffee and caffeine intake and the risk of COPD and lung function has not been thoroughly discussed in Americans, with subgroup and threshold effects remaining unclear.

Objectives

This study investigated the association between coffee and caffeine consumption and the risk of chronic obstructive pulmonary disease (COPD) as well as lung function utilizing data from the NHANES 2007–2012.

Methods

We assessed the associations of coffee and caffeine consumption with the risk of COPD and lung function parameters, including FEV1 and FVC, adjusting for common demographic and disease characteristics in a cross-sectional analysis of NHANES data.

Results

A total of 9763 participants were included in the study, and 592 were diagnosed with COPD. Multivariate regression models revealed positive associations between coffee and caffeine consumption and the risk of COPD and lung function. Subgroup analyses stratified by sex, DM, hypertension status, and smoking habits identified potential effect modifiers as well as inflection points from threshold effect examinations.

Conclusions

The results of this cross-sectional study indicated significant positive correlations between coffee and caffeine consumption and the risk of COPD. Additionally, positive correlations between exposure variables and FEV1 and FVC were detected. Among the stratification factors, smoking status exhibited the most potential for modifying effects. Future practices and research are needed to validate the results and explore the underlying mechanisms

查看原文本刊更多论文

咖啡和咖啡因摄入量与慢性阻塞性肺病风险之间的关系：基于 2007-2012 年国家健康调查（NHANES）的研究结果

背景美国人对咖啡和咖啡因摄入量与慢性阻塞性肺病（COPD）风险和肺功能之间的关系尚未进行深入探讨，亚组效应和阈值效应尚不明确。方法我们通过对 NHANES 数据进行横断面分析，评估了咖啡和咖啡因的摄入量与慢性阻塞性肺病风险以及肺功能参数（包括 FEV1 和 FVC）之间的关系，并对常见的人口统计学特征和疾病特征进行了调整。多变量回归模型显示，咖啡和咖啡因的摄入量与慢性阻塞性肺病的发病风险和肺功能呈正相关。按性别、糖尿病、高血压状态和吸烟习惯进行的亚组分析确定了潜在的效应调节因子以及阈值效应检查的拐点。结论这项横断面研究的结果表明，咖啡和咖啡因的摄入量与慢性阻塞性肺病的发病风险之间存在显著的正相关。此外，还发现暴露变量与 FEV1 和 FVC 之间存在正相关。在分层因素中，吸烟状况最有可能产生调节作用。未来的实践和研究需要验证这些结果并探索其潜在机制

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464