Insights into multilevel spatial regulation within the root stem cell niche

IF 3.7 2区 生物学 Q2 CELL BIOLOGY
Jessica Pérez-Sancho , Lisa Van den Broeck , Pedro García-Caparros , Rosangela Sozzani
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引用次数: 0

Abstract

All differentiated root cells derive from stem cells spatially organized within the stem cell niche (SCN), a microenvironment located within the root tip. Here, we compiled recent advances in the understanding of how the SCN drives the establishment and maintenance of cell types. The quiescent center (QC) is widely recognized as the primary driver of cell fate determination, but it is recently considered a convergence center of multiple signals. Cell identity of the cortex endodermis initials is mainly driven by the regulatory feedback loops between transcription factors (TFs), acting as mobile signals between neighboring cells, including the QC. As exemplified in the vascular initials, the precise spatial expression of these regulatory TFs is connected with a dynamic hormonal interplay. Thus, stem cell maintenance and cell differentiation are regulated by a plethora of signals forming a complex, multilevel regulatory network. Integrating the transcriptional and post-translational regulations, protein–protein interactions, and mobile signals into models will be fundamental for the comprehensive understanding of SCN maintenance and differentiation.

对根干细胞生态位内多层次空间调控的见解
所有分化的根细胞都来源于干细胞龛(SCN)中的干细胞,干细胞龛是位于根尖的微环境。在此,我们汇编了在了解SCN如何驱动细胞类型的建立和维持方面的最新进展。静止中心(QC)被广泛认为是细胞命运决定的主要驱动力,但最近又被认为是多种信号的汇聚中心。皮层内胚层初生细胞的细胞特性主要由转录因子(TFs)之间的调控反馈回路驱动,这些转录因子是相邻细胞(包括 QC)之间的移动信号。以血管初生细胞为例,这些调控转录因子的精确空间表达与动态激素相互作用有关。因此,干细胞的维持和细胞分化受到大量信号的调控,形成了一个复杂的多级调控网络。将转录和翻译后调控、蛋白-蛋白相互作用以及移动信号整合到模型中,将是全面了解SCN维持和分化的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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