Linxuan Wu, John Kinuthia, Peter L Anderson, Jared M Baeten, Julia C Dettinger, Monica Gandhi, Laurén Gomez, Grace John-Stewart, Mary M Marwa, Nancy Ngumbau, Felix Otieno, Pascal Omondi, Ben Odhiambo, Salphine Watoyi, Jillian Pintye
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引用次数: 0
Abstract
We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV pre-exposure prophylaxis (PrEP) during pregnancy and postpartum and compared hair levels with tenofovir-diphosphate (TFV-DP) levels in dried blood spots (DBS). Overall, 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster randomized trial. Having a partner known to be living with HIV was associated with higher hair TFV levels (p<0.001). Hair TFV concentrations were strongly correlated with DBS TFV-DP levels (r=0.76, p<0.001), indicating hair as promising cumulative adherence metric for perinatal PrEP assessment.
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