Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2024-05-02 DOI:10.1016/j.devcel.2024.04.012

Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J. Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader

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Abstract

The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV₂ formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1^−/− hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1^−/− and cox7a2l^−/− underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.

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Cox7a1通过复合体IV二聚化控制骨骼肌生理机能和心脏再生

氧化磷酸化（OXPHOS）系统的组织结构错综复杂，呼吸复合物形成了超级组装的四元结构，其组装机制和生理作用仍在研究之中。Cox7a2l又称Scaf1，可促进复合物III和复合物IV（CIII-CIV）的超级组装，提高各种物种的能量效率。我们研究了 Cox7a 家族的另一个成员 Cox7a1 在超级复合体组装和肌肉生理学中的作用。缺乏 Cox7a1 的斑马鱼表现出 CIV2 形成减少、代谢改变和非病理性肌肉性能下降。此外，cox7a1-/-心脏显示出有利于再生的代谢特征，影响了心脏再生反应。cox7a1-/-和cox7a2l-/-的不同表型效应强调了超级复合体形成受损所导致的不同代谢和生理后果，同时强调了Cox7a1在OXPHOS系统内肌肉成熟过程中的重要性。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.

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