Strengthening preclinical testing to increase safety in surgical mesh

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-05-01 DOI:10.1038/s41585-024-00889-5

Nicholas T. H. Farr, Victoria L. Workman, Christopher R. Chapple, Sheila MacNeil, Cornelia Rodenburg

引用次数: 0

Abstract

Inflammatory and fibrotic responses to polypropylene mesh led to the withdrawal of this practice for treatment of stress urinary incontinence and pelvic organ prolapse in women in some countries. Improved material testing has been urged. We report poor responses of polypropylene mesh to repeated mechanical distension and macrophage interrogation. These results from preclinical in vitro testing show the potential of this approach for testing and improving materials before their introduction into the clinic.

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加强临床前测试，提高手术网片的安全性

聚丙烯网片引起的炎症和纤维化反应导致一些国家不再采用这种方法治疗女性压力性尿失禁和盆腔器官脱垂。人们敦促改进材料测试。我们报告了聚丙烯网片对反复机械拉伸和巨噬细胞检测的不良反应。这些临床前体外测试的结果表明，在将材料引入临床之前，这种方法具有测试和改进材料的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.