Live to fight another day: The bacterial nucleoid under stress

IF 2.6 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Microbiology Pub Date : 2024-05-01 DOI:10.1111/mmi.15272

Azra M. Walker, Elio A. Abbondanzieri, Anne S. Meyer

引用次数: 0

Abstract

The bacterial chromosome is both highly supercoiled and bound by an ensemble of proteins and RNA, causing the DNA to form a compact structure termed the nucleoid. The nucleoid serves to condense, protect, and control access to the bacterial chromosome through a variety of mechanisms that remain incompletely understood. The nucleoid is also a dynamic structure, able to change both in size and composition. The dynamic nature of the bacterial nucleoid is particularly apparent when studying the effects of various stresses on bacteria, which require cells to protect their DNA and alter patterns of transcription. Stresses can lead to large changes in the organization and composition of the nucleoid on timescales as short as a few minutes. Here, we summarize some of the recent advances in our understanding of how stress can alter the organization of bacterial chromosomes.

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为新的一天而战压力下的细菌核仁

细菌染色体是高度超卷曲的，并被一系列蛋白质和 RNA 结合在一起，使 DNA 形成一个紧凑的结构，称为核团。核膜通过各种机制凝结、保护和控制对细菌染色体的访问，这些机制至今仍不完全清楚。类核也是一种动态结构，其大小和组成都会发生变化。细菌核团的动态特性在研究各种压力对细菌的影响时尤为明显，这些压力要求细胞保护其 DNA 并改变转录模式。应激可导致核团的组织和组成在短短几分钟内发生巨大变化。在此，我们总结了最近在理解应激如何改变细菌染色体组织方面取得的一些进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Microbiology 生物-生化与分子生物学

CiteScore

7.20

自引率

5.60%

发文量

132

审稿时长

1.7 months

期刊介绍： Molecular Microbiology, the leading primary journal in the microbial sciences, publishes molecular studies of Bacteria, Archaea, eukaryotic microorganisms, and their viruses. Research papers should lead to a deeper understanding of the molecular principles underlying basic physiological processes or mechanisms. Appropriate topics include gene expression and regulation, pathogenicity and virulence, physiology and metabolism, synthesis of macromolecules (proteins, nucleic acids, lipids, polysaccharides, etc), cell biology and subcellular organization, membrane biogenesis and function, traffic and transport, cell-cell communication and signalling pathways, evolution and gene transfer. Articles focused on host responses (cellular or immunological) to pathogens or on microbial ecology should be directed to our sister journals Cellular Microbiology and Environmental Microbiology, respectively.