Exploring the role of OXTR gene methylation in attachment development: A longitudinal study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-30 DOI:10.1002/dev.22496

Bien Cuyvers, Tsachi Ein-Dor, Melisse Houbrechts, Kathleen Freson, Luc Goossens, Wim Van Den Noortgate, Karla van Leeuwen, Patricia Bijttebier, Stephan Claes, Jonathan Turner, Viktoria Chubar, Marian J. Bakermans-Kranenburg, Guy Bosmans

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引用次数: 0

Abstract

The current study explored longitudinally whether oxytocin receptor gene methylation (OXTRm) changes moderated the association between parental sensitivity changes and children's attachment changes over three waves. Six hundred six Flemish children (10–12 years, 42.8%–44.8% boys) completed attachment measures and provided salivary OXTRm data on seven CpG sites. Their parents reported their sensitive parenting. Results suggest that OXTRm changes hardly link to attachment (in)security changes after the age of 10. Some support was found for interaction effects between parental sensitivity changes and OXTRm changes on attachment changes over time. Effects suggest that for children with increased OXTRm in the promotor region and decreased methylation in the inhibitor region over time, increased parental sensitivity was associated with increased secure attachment and decreased insecure attachment over time.

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探索 OXTR 基因甲基化在依恋发展中的作用：纵向研究

本研究纵向探讨了催产素受体基因甲基化（OXTRm）的变化是否会在三个波次中调节父母敏感性变化与儿童依恋变化之间的关联。600 名佛兰德儿童（10-12 岁，42.8%-44.8% 为男孩）完成了依恋测量，并提供了唾液中七个 CpG 位点的 OXTRm 数据。他们的父母则报告了他们敏感的养育方式。结果表明，OXTRm 的变化很难与 10 岁以后依恋（不）安全感的变化联系起来。父母的敏感性变化和 OXTRm 变化之间的交互作用对依恋随着时间的推移而发生的变化有一定的支持作用。结果表明，随着时间的推移，OXTRm在启动子区域的甲基化程度增加而在抑制剂区域的甲基化程度降低的儿童，其父母敏感性的增加与安全依恋的增加和不安全依恋的减少有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.