Polysensitisation is associated with more severe symptoms: The reality of patients with allergy

IF 6.3 2区医学 Q1 ALLERGY

Clinical and Experimental Allergy Pub Date : 2024-04-27 DOI:10.1111/cea.14486

Cristina Cacheiro-Llaguno, Ralph Mösges, David Calzada, Sandra González-de la Fuente, Eliana Quintero, Jerónimo Carnés

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Abstract

Background

Studying the sensitisation profiles of patients with allergies allows for a deeper understanding of the disease which may facilitate the selection of the best-personalised allergen immunotherapy. This observational, cross-sectional, multicentre study aimed to demonstrate the heterogeneity of the German population with allergies by analysing specific immunoglobulin E (sIgE) patterns towards aeroallergens and exploring the relationship between sensitisation and clinical symptoms.

Methods

In total, 500 patients with allergies from different regions of Germany were recruited based on their case histories, clinical allergic symptoms and skin prick test data for aeroallergens. Serum samples were analysed using ImmunoCAP assays to determine sIgE levels for 33 allergenic sources and 43 molecular allergens.

Results

Most patients (81%) were polysensitised. Betula verrucosa pollen was the most common cause of sensitisation (59%), followed by Phleum pratense (58%) and Dermatophagoides pteronyssinus (44%). The highest prevalence rates of molecular allergens were observed for Bet v 1 (84%) from birch pollen, Phl p 1 from grass pollen (82%), Der p 2 (69%) from mites and Fel d 1 (69%) from cat. Polysensitisation was significantly associated with the presence of asthma and the severity of rhinitis symptoms.

Conclusions

Our findings show a high rate of polysensitisation and emphasise the importance of molecular diagnosis for more precise and comprehensive insights into sensitisation patterns and their association with clinical symptoms. These data may help improve personalised diagnosis and immunotherapy adapted to the needs of individual patients in the region.

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多过敏与更严重的症状有关：过敏症患者的实际情况

背景研究过敏症患者的致敏特征可以加深对过敏症的了解，从而有助于选择最适合个人的过敏原免疫疗法。这项观察性、横断面、多中心研究旨在通过分析过敏原特异性免疫球蛋白 E (sIgE) 的模式，探讨过敏与临床症状之间的关系，从而证明德国过敏症患者的异质性。方法根据病史、临床过敏症状和过敏原皮肤点刺试验数据，从德国不同地区共招募了 500 名过敏症患者。使用 ImmunoCAP 检测法对血清样本进行分析，以确定 33 种过敏源和 43 种分子过敏原的 sIgE 水平。桦树花粉是最常见的致敏原因（59%），其次是箭毒花粉（58%）和翼蝽花粉（44%）。分子过敏原中，桦树花粉中的 Bet v 1（84%）、草花粉中的 Phl p 1（82%）、螨虫中的 Der p 2（69%）和猫身上的 Fel d 1（69%）的致敏率最高。结论：我们的研究结果表明，多致敏率很高，并强调了分子诊断对于更精确、更全面地了解致敏模式及其与临床症状的关系的重要性。这些数据可能有助于改进个性化诊断和免疫疗法，以满足该地区患者的不同需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Allergy 医学-过敏

CiteScore

10.40

自引率

9.80%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Allergy strikes an excellent balance between clinical and scientific articles and carries regular reviews and editorials written by leading authorities in their field. In response to the increasing number of quality submissions, since 1996 the journals size has increased by over 30%. Clinical & Experimental Allergy is essential reading for allergy practitioners and research scientists with an interest in allergic diseases and mechanisms. Truly international in appeal, Clinical & Experimental Allergy publishes clinical and experimental observations in disease in all fields of medicine in which allergic hypersensitivity plays a part.