Relationship between Thyroid Feedback Quantile-based Index and cardiovascular diseases in a population with normal thyroid function: Evidence from the National Health and Nutrition Examination Survey 2007–2012

IF 2.4 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Clinical Cardiology Pub Date : 2024-04-28 DOI:10.1002/clc.24271

Hui Li PhD, Xue Liu MD, Xinhui Wang MD, Qingqing Yang PhD

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Abstract

Background

Previous study has demonstrated a link between TFQI, indicating the central sensitivity of thyroid hormones, and conditions like obesity, diabetes, and metabolic syndrome.

Hypothesis

Nevertheless, the potential relationship between TFQI and cardiovascular disease (CVD) in individuals with normal thyroid function has yet to be established.

Methods

The present research is a retrospective cohort investigation that included a total of 6297 individuals who had normal function of the thyroid and no history of thyroid disorders. These participants were selected from National Health and Nutrition Examination Survey data set, covering the years 2007–2012. The calculation of TFQI was performed depending on FT4 and TSH. Given the complex survey design and sample weights, we used multivariate linear regression models and stratified analysis to evaluate TFQI's correlation with CVD.

Results

Subjects with CVD had greater levels of TFQI than those with no CVD. After adjusting for other covariates, TFQI exhibited a positive association with CVD risk, and the OR was 1.706 (p = .005). In subgroup analyses that were stratified by sex and BMI, it was shown that female individuals who had CVD had greater levels of TFQI in comparison to female participants without CVD (p = .002). Furthermore, elevated levels of TFQI were consistently connected to a raised incidence of CVD in the BMI (>28 kg/m²) group after regulating for different covariates. Furthermore, correlation analysis showed an association between TFQI and metabolic biomarkers.

Conclusions

The levels of TFQI are strongly connected to the prevalence of CVD, indicating that energy metabolism may be related to the occurrence of CVD.

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甲状腺功能正常人群中甲状腺反馈定量指数与心血管疾病之间的关系：来自 2007-2012 年全国健康与营养调查的证据

背景以前的研究表明，TFQI（表明甲状腺激素的中心敏感性）与肥胖、糖尿病和代谢综合征等疾病之间存在联系。假设尽管如此，甲状腺功能正常者的 TFQI 与心血管疾病（CVD）之间的潜在关系仍有待确定。方法本研究是一项回顾性队列调查，共纳入了 6297 名甲状腺功能正常且无甲状腺疾病史的人。这些参与者选自 2007-2012 年全国健康与营养调查数据集。TFQI的计算取决于FT4和TSH。考虑到复杂的调查设计和样本权重，我们使用多元线性回归模型和分层分析来评估TFQI与心血管疾病的相关性。结果患有心血管疾病的受试者的 TFQI 水平高于未患心血管疾病的受试者。调整其他协变量后，TFQI 与心血管疾病风险呈正相关，OR 值为 1.706（p = .005）。在按性别和体重指数分层的亚组分析中显示，与未患心血管疾病的女性参与者相比，患心血管疾病的女性参与者的 TFQI 水平更高（p = .002）。此外，在对不同的协变量进行调节后，TFQI水平的升高与BMI（28 kg/m2）组心血管疾病发病率的升高有着一致的联系。此外，相关分析表明 TFQI 与代谢生物标志物之间存在关联。结论 TFQI 的水平与心血管疾病的发病率密切相关，表明能量代谢可能与心血管疾病的发生有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Cardiology 医学-心血管系统

CiteScore

5.10

自引率

3.70%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Clinical Cardiology provides a fully Gold Open Access forum for the publication of original clinical research, as well as brief reviews of diagnostic and therapeutic issues in cardiovascular medicine and cardiovascular surgery. The journal includes Clinical Investigations, Reviews, free standing editorials and commentaries, and bonus online-only content. The journal also publishes supplements, Expert Panel Discussions, sponsored clinical Reviews, Trial Designs, and Quality and Outcomes.