{"title":"Oxygen-Dependent Aspects of Asprosin Action","authors":"V. V. Zinchuk, J. S. O. Al-Jebur","doi":"10.1134/s0022093024020297","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Asprosin, a novel adipokine secreted mainly by white adipose\ntissue, regulates organismal responses to short-term fasting, initiates\nglucose synthesis and/or release from the liver and thus stimulates\nappetite, increases total energy reserves in adipose tissue. Determining\nthe bioenergetic status of the organism, this hormone influences\ntissue oxygen content and, accordingly, oxygen-transporting function\nof blood in the case of overweight and insulin resistance. Individuals\nwith an increased asprosin content associated with overweight and\nclass 1 obesity, as well as insulin resistance, demonstrate a shift\nof the oxygen–hemoglobin dissociation curve, accompanied by an increase\nin the blood concentration of nitrogen monoxide gasotransmitter\nand a decrease in hydrogen sulfide levels. Asprosin is involved\nin the regulation of the gasotransmitter system and shaping the\nmechanisms for blood oxygen transport. Asprosin contribution to\nthe formation oxygen supply and adaptive reserves in individuals\nwith metabolic disorders reflects a new aspect of the mechanism\nof its action.</p>","PeriodicalId":15805,"journal":{"name":"Journal of Evolutionary Biochemistry and Physiology","volume":"36 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Evolutionary Biochemistry and Physiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s0022093024020297","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Asprosin, a novel adipokine secreted mainly by white adipose
tissue, regulates organismal responses to short-term fasting, initiates
glucose synthesis and/or release from the liver and thus stimulates
appetite, increases total energy reserves in adipose tissue. Determining
the bioenergetic status of the organism, this hormone influences
tissue oxygen content and, accordingly, oxygen-transporting function
of blood in the case of overweight and insulin resistance. Individuals
with an increased asprosin content associated with overweight and
class 1 obesity, as well as insulin resistance, demonstrate a shift
of the oxygen–hemoglobin dissociation curve, accompanied by an increase
in the blood concentration of nitrogen monoxide gasotransmitter
and a decrease in hydrogen sulfide levels. Asprosin is involved
in the regulation of the gasotransmitter system and shaping the
mechanisms for blood oxygen transport. Asprosin contribution to
the formation oxygen supply and adaptive reserves in individuals
with metabolic disorders reflects a new aspect of the mechanism
of its action.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
