Adaptive Blood Cell Variability in the Annual Life Cycle of the Ground Squirrel Urocitellus undulatus

IF 0.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Evolutionary Biochemistry and Physiology Pub Date : 2024-04-26 DOI:10.1134/s0022093024020017

P. O. Teplova, N. P. Komelina, A. Ye. Yegorov, K. I. Lizorkina, N. M. Zakharova

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Abstract

The complete blood count (CBC) dynamics was investigated in long-tailed ground squirrels Urocitellus undulatus (n = 100) during different periods of their annual activity. While blood cell (WBC), platelet (PLT), and red blood cell (RBC) counts were determined in summer (normothermia, June–July), fall (preparatory period, October), winter torpor (hypothermia, December–February) and winter active (euthermia, interbout arousals, December–February) periods. In fall, PLT and WBC counts increased by ~40% compared to summer. Under winter torpor, thrombocytosis and leukocytosis were replaced by extreme thrombocytopenia (↓ ~90%), as well as leukopenia in all WBC subpopulations (↓ ~80%). During brief interbout arousals, PLT and WBC counts reached the summer values except for a slightly increased MPV (mean platelet volume). As fall approached, there was an insignificant erythrocytosis (↑ ~10%), which together with changes in other indices could have suggested a mild fall-time hypoxia. During winter torpid and euthermic periods, RBC counts were almost indistinguishable from the summer control values, however, atypical RBC forms occurred both in the fall preparatory period and during hibernation itself. The results are discussed in the context of blood cell adaptation to harsh conditions of hibernation in ground squirrels, and can be useful in studying the adaptive abilities of homoeotherms, including humans.

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地松鼠 Urocitellus undulatus 一年生命周期中的适应性血细胞变异性

摘要研究了长尾地松鼠（Urocitellusundulatus，n = 100）在不同活动时期的全血细胞计数（CBC）动态。在夏季（常温，6 月至 7 月）、秋季（准备期，10 月）、冬季冬眠（低温，12 月至 2 月）和冬季活动期（呼热，唤醒间歇期，12 月至 2 月）测定了血细胞（WBC）、血小板（PLT）和红细胞（RBC）计数。与夏季相比，秋季的血小板和白细胞计数增加了约 40%。在冬季，血小板减少和白细胞减少被极度血小板减少（↓ ~90%）和所有白细胞亚群的白细胞减少（↓ ~80%）所取代。在短暂的蛙间唤醒期，除了 MPV（平均血小板体积）略有增加外，PLT 和白细胞计数达到了夏季的值。随着秋季的临近，出现了轻微的红细胞增多症（↑ ~10%），再加上其他指标的变化，这可能意味着秋季出现了轻度缺氧。在冬季休眠期和热休眠期，红细胞计数与夏季对照值几乎没有区别，但在秋季准备期和冬眠期间，红细胞形态不典型。这些结果是在地松鼠血细胞适应冬眠恶劣条件的背景下讨论的，对研究包括人类在内的同温动物的适应能力很有帮助。

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来源期刊

Journal of Evolutionary Biochemistry and Physiology 生物-进化生物学

自引率

33.30%

发文量

110

审稿时长

6-12 weeks

期刊介绍： Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.