Amniotic Membrane Augmentation for Enucleation After Chemotherapy in Retinoblastoma

Journal of Pediatric Ophthalmology and Strabismus Pub Date : 2024-04-25 DOI:10.3928/01913913-20240307-01

Aparna Ramasubramanian, MD, Nisha S. Rehman, MD, Argudit Chauhan, BS, Aurora Rodriguez, BS, Amy Leverant, MD, Nishant Tiwari, MD

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Abstract

Purpose:

To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma.

Methods:

This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma.

Results:

In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation. Amniotic graft was used in 8 eyes (5 following IAC, 2 following systemic chemotherapy, and 1 after both). After IAC, 3 of 7 eyes without amniotic graft had implant exposure compared to 0 of 6 eyes with amniotic graft (P = .05). Pathological examination of the conjunctiva after intra-arterial chemotherapy showed goblet cell hypoplasia that hinders wound healing.

Conclusions:

Amniotic membrane augmentation improves wound integrity in patients with retinoblastoma, especially following intra-arterial chemotherapy.

[J Pediatr Ophthalmol Strabismus. 20XX;X(X):XXX–XXX.]

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视网膜母细胞瘤化疗后的羊膜增生去核术

目的：描述视网膜母细胞瘤患者化疗后进行去核手术时的羊膜增殖术。方法：这是一项对接受去核手术的视网膜母细胞瘤患者进行的回顾性研究。研究还评估了羊膜移植在视网膜母细胞瘤患者化疗后去核术中的实用性。结果：本研究分析了107名患者的110只眼睛，其中49名患者曾接受过全身化疗，13只眼睛曾接受过动脉内化疗，7只眼睛曾接受过外照射。8只眼睛使用了羊膜移植（5只在IAC后，2只在全身化疗后，1只在两者都使用后）。IAC 后，7 只未使用羊膜移植的眼睛中有 3 只出现植入物暴露，而使用羊膜移植的 6 只眼睛中只有 0 只出现这种情况（P = .05）。结论：羊膜移植可改善视网膜母细胞瘤患者伤口的完整性，尤其是在动脉内化疗后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Pediatric Ophthalmology and Strabismus

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