Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism—Association with prostate cancer

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-04-23 DOI:10.1016/j.etap.2024.104455

Beatriz Álvarez-González , Antonio F. Hernández , Alberto Zafra-Gómez , Lucia Chica-Redecillas , Sergio Cuenca-López , Fernando Vázquez-Alonso , Luis Javier Martínez-González , María Jesús Álvarez-Cubero

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Abstract

This study assessed whether genetic variants coding for certain enzymes involved in xenobiotic detoxification, antioxidant defences and DNA repair, along with exposure to environmental chemicals, were associated with an increased prostate cancer (PCa) risk. The study population consisted of 300 men (150 PCa cases and 150 controls) which underwent prostate biopsy as their serum prostate specific antigen (PSA) levels were greater than 4 ng/ml. Genetic variants in GSTM1, GSTP1, SOD2, CAT, GPX1, XRCC1 were determined and data for chemical exposures was obtained through a structured questionnaire and by biomonitoring in a subsample of cases and controls. High serum PSA levels were associated with a greater risk of PCa, while physical exercise appears to exert a protective effect against its development. In addition, elevated urinary levels of certain organic pollutants, such as benzo(a)pyrene (BaP), bisphenol A (BPA), and ethyl-paraben (EPB), were associated with an increased risk of PCa.

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暴露于环境污染物以及与氧化应激和异种生物代谢有关的基因变异--与前列腺癌的关系。

这项研究评估了编码某些参与异生物解毒、抗氧化防御和DNA修复的酶的基因变异，以及暴露于环境化学物质是否与前列腺癌（PCa）风险增加有关。研究对象包括300名男性（150名PCa病例和150名对照组），他们的血清前列腺特异性抗原（PSA）水平高于4纳克/毫升，因此接受了前列腺活组织检查。研究人员测定了 GSTM1、GSTP1、SOD2、CAT、GPX1 和 XRCC1 的基因变异，并通过结构化问卷和生物监测获得了部分病例和对照组的化学接触数据。高血清 PSA 水平与 PCa 的高风险相关，而体育锻炼似乎对 PCa 的发生有保护作用。此外，尿液中某些有机污染物（如苯并（a）芘（BaP）、双酚 A（BPA）和乙基对羟基苯甲酸酯（EPB））水平的升高与 PCa 风险的增加有关。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.