The impact of COVID-19 pandemic on women with endometriosis: a retrospective cohort study on referral center population.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ludovica Spanò Bascio, Sofia Gambigliani Zoccoli, Rosamaria Pellegrini, A. Farulla, Marianna Cannoletta, Laura Paterlini, A. La Marca, Carlo Alboni
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Abstract

BACKGROUND Patients with endometriosis are thought to have been impacted by the COVID-19 pandemic and estimates suggest that 6.2% of them were infected with SARS-CoV-2. METHODS This is a retrospective cohort study enrolling 284 women at the Polyclinic of Modena between January 2020 and April 2021. Patients were given specific questionnaires to investigate COVID-19 infection and any changes in gynecological symptoms. All patients were also administered the Hospital Anxiety and Depression Syndrome (HADS) Questionnaire to assess the psychological impact of the COVID-19 pandemic. The primary outcome was to assess the clinical impact and any worsening of gynecological symptoms after COVID-19 infection; the secondary outcome was to evaluate the clinical and psychological impact of the COVID-19 pandemic in patients with endometriosis or chronic pelvic pain. RESULTS A total of 170 women experienced COVID-19 infection, while 114 were consistently negative and asymptomatic for COVID-19. The two groups showed similar baseline. A total of 122 women with COVID-19 infection and 106 COVID-19 negative patients had already the vaccine administration with two doses of vaccine (72.20% vs. 93%, P=0.001). Among the 170 patients affected by COVID-19, 41 (24%) reported worsening gynecologic endometriosis symptoms, during the infection. According to our results, 196 of 284 reported changes in their gynecological health status during pandemic, and 84 reported symptomatic worsening (42.9%); 24% of patients with infection reported feeling slowed down vs. 15.8% of unaffected patients (P=0.065) and 44% of positive patients reported loss of interest in self-care vs. 31% of negative patients (P=0.055). CONCLUSIONS Patients with endometriosis seemed to have worsening gynecological and psychological clinical status during the pandemic.
COVID-19大流行对子宫内膜异位症妇女的影响:一项针对转诊中心人群的回顾性队列研究。
背景子宫内膜异位症患者被认为受到了 COVID-19 大流行的影响,据估计,其中 6.2% 的患者感染了 SARS-CoV-2 病毒。方法这是一项回顾性队列研究,在 2020 年 1 月至 2021 年 4 月期间,摩德纳综合医院招募了 284 名女性患者。对患者进行了专门的问卷调查,以了解 COVID-19 感染情况和妇科症状的变化。所有患者还接受了医院焦虑和抑郁综合征(HADS)问卷调查,以评估 COVID-19 大流行对患者的心理影响。主要结果是评估感染COVID-19后妇科症状的临床影响和恶化情况;次要结果是评估COVID-19大流行对子宫内膜异位症或慢性盆腔痛患者的临床和心理影响。两组的基线相似。共有 122 名感染 COVID-19 的妇女和 106 名 COVID-19 阴性患者已接种过两剂疫苗(72.20% 对 93%,P=0.001)。在感染 COVID-19 的 170 名患者中,有 41 人(24%)报告在感染期间妇科子宫内膜异位症症状加重。根据我们的结果,284 名患者中有 196 人报告在大流行期间他们的妇科健康状况发生了变化,其中 84 人报告症状恶化(42.9%);24% 的感染患者报告感觉行动迟缓,而未受影响的患者报告感觉行动迟缓的比例为 15.8%(P=0.结论子宫内膜异位症患者在大流行期间的妇科和心理临床状况似乎有所恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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