Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment

IF 6.9 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2024-04-15 DOI:10.1016/j.gendis.2024.101309

Ling Li , Bing Han , Yan Kong , Gaojia Zhang , Zhijun Zhang

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引用次数: 0

Abstract

Vitamin D binding protein (VDBP) serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target organs. VDBP plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin degradation. Recent research has shed light on its potential role in various diseases, leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological disorders. The purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric disorders. By examining the intricate interplay between VDBP and these disorders, this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic avenues. Insights gained from the study of VDBP could pave the way for novel strategies in the diagnosis, prognosis, and treatment of psychiatric and neurological disorders.

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精神和神经疾病中的维生素 D 结合蛋白：对诊断和治疗的影响

维生素 D 结合蛋白（VDBP）是一种关键的转运蛋白，负责结合维生素 D 及其代谢物并将其输送到目标器官。VDBP 在组织损伤后的炎症反应中起着至关重要的作用，并参与肌动蛋白降解。最近的研究揭示了 VDBP 在各种疾病中的潜在作用，因此人们对了解 VDBP 在精神和神经疾病中的影响越来越感兴趣。本综述旨在总结现有的关于 VDBP 参与神经和精神疾病的认识。通过研究 VDBP 与这些疾病之间错综复杂的相互作用，本综述有助于加深对潜在机制和潜在治疗途径的理解。从 VDBP 研究中获得的见解可为精神和神经疾病的诊断、预后和治疗的新策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.