Investigating the cyto-compatibility of ZrNbVTiAl high entropy alloy

P. Chakraborty , R.K. Chittela , S. Samal , A. Sarkar , A.V.S.S.N. Rao , S. Neogy , R. Tewari
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Abstract

An investigation was carried out to assess the suitability of equiatomic ZrNbVTiAl high-entropy alloy (HEA) for biomedical applications. This included microstructural analysis, mechanical property evaluation and in–vivo testing in biological media to examine its cyto-compatibility. The alloy developed a dendritic structure on solidification through arc melting, with BCC –B2 type dendrites separated by inter-dendritic regions rich in Al and Zr. The evolved microstructure and composition matched well with those predicted by the phase field modelling. The HEA also showed a high yield strength (1045 MPa) and moderate elastic modulus (120 GPa) comparable to the commonly used biomedical alloy, Ti-6Al-4 V. Cell culture studies with U2OS Cells showed substantial attachment and growth of healthy osteoblasts to the HEA as well as negligible bio-corrosion after 45 days of exposure. Most importantly, the alloy showed a significantly high tendency of cell attachment than pure Ti and lower magnetic susceptibility (2.55 ×10−6 cm3/g) than Ti-6Al-4 V alloy indicating its suitability for biomedical applications.

研究 ZrNbVTiAl 高熵合金的细胞相容性
为了评估等原子 ZrNbVTiAl 高熵合金 (HEA) 在生物医学应用中的适用性,我们进行了一项调查。这包括微观结构分析、机械性能评估以及在生物介质中进行体内测试,以检查其细胞相容性。通过电弧熔化,合金在凝固过程中形成了树枝状结构,树枝状结构为 BCC -B2 型,树枝状结构之间由富含 Al 和 Zr 的树枝状区域分隔。演化出的微观结构和成分与相场建模预测的结果十分吻合。HEA 还显示出较高的屈服强度(1045 兆帕)和适中的弹性模量(120 千兆帕),与常用的生物医学合金 Ti-6Al-4 V 相当。使用 U2OS 细胞进行的细胞培养研究表明,健康的成骨细胞在 HEA 上有大量附着和生长,暴露 45 天后的生物腐蚀可忽略不计。最重要的是,该合金的细胞附着倾向明显高于纯 Ti,磁感应强度(2.55 ×10-6 cm3/g)也低于 Ti-6Al-4 V 合金,这表明它适合生物医学应用。
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