BUPROPION INDUCED DELAYED ONSET URTICARIA: A CASE REPORT

Abstract

Bupropion is an oral antidepressant which acts by inhibiting the reuptake of dopamine and noradrenaline from synapse. Apart from treatment of depressive disorders, it is used off-label for smoking cessation, treatment of attention-decit hyperactivity disorder and obesity. Bupropion is generally well-tolerated and has a favorable safety prole. Till date there have only been few case reports of allergic skin reactions associated with bupropion. Apart from being a rare adverse reaction, the unique feature of delayed onset of allergic reaction may lead to underreporting of the phenomenon. Here we present a case report of a 30 years old male who presented with generalized urticaria after twenty-three days of bupropion initiation. This report serves to promote awareness among the clinicians about the association of delayed-onset allergic phenomenon with use of Bupropion.