Mechanisms of intestinal epithelial cell damage by Clostridium perfringens

IF 2.5 3区生物学 Q3 MICROBIOLOGY

Anaerobe Pub Date : 2024-04-10 DOI:10.1016/j.anaerobe.2024.102856

Lanxin Ou , Bijin Ye , Mingfei Sun , Nanshan Qi , Juan Li , Minna Lv , Xuhui Lin , Haiming Cai , Junjing Hu , Yongle Song , Xiangjie Chen , Yibin Zhu , Lijun Yin , Jianfei Zhang , Shenquan Liao , Haoji Zhang

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Abstract

Clostridium perfringens, a Gram-positive bacterium, causes intestinal diseases in humans and livestock through its toxins, related to alpha toxin (CPA), beta toxin (CPB), C. perfringens enterotoxin (CPE), epsilon toxin (ETX), Iota toxin (ITX), and necrotic enteritis B-like toxin (NetB). These toxins disrupt intestinal barrier, leading to various cell death mechanisms such as necrosis, apoptosis, and necroptosis. Additionally, non-toxin factors like adhesins and degradative enzymes contribute to virulence by enhancing colonization and survival of C. perfringens. A vicious cycle of intestinal barrier breach, misregulated cell death, and subsequent inflammation is at the heart of chronic inflammatory and infectious gastrointestinal diseases. Understanding these mechanisms is essential for developing targeted therapies against C. perfringens-associated intestinal diseases.

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产气荚膜梭菌损伤肠上皮细胞的机制

产气荚膜梭菌（Clostridium perfringens）是一种革兰氏阳性细菌，通过其毒素（α毒素（CPA）、β毒素（CPB）、产气荚膜梭菌肠毒素（CPE）、epsilon毒素（ETX）、Iota毒素（ITX）和坏死性肠炎B样毒素（NetB））引起人类和家畜的肠道疾病。这些毒素会破坏肠道屏障，导致各种细胞死亡机制，如坏死、凋亡和坏死突变。此外，粘附素和降解酶等非毒素因子可增强产气荚膜杆菌的定植和存活，从而增强其毒力。肠道屏障破坏、细胞死亡失调和随后的炎症形成恶性循环，这是慢性炎症性和传染性胃肠道疾病的核心所在。了解这些机制对于开发针对C.perfringens相关肠道疾病的靶向疗法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaerobe 生物-微生物学

CiteScore

5.20

自引率

8.70%

发文量

137

审稿时长

76 days

期刊介绍： Anaerobe is essential reading for those who wish to remain at the forefront of discoveries relating to life processes of strictly anaerobes. The journal is multi-disciplinary, and provides a unique forum for those investigating anaerobic organisms that cause infections in humans and animals, as well as anaerobes that play roles in microbiomes or environmental processes. Anaerobe publishes reviews, mini reviews, original research articles, notes and case reports. Relevant topics fall into the broad categories of anaerobes in human and animal diseases, anaerobes in the microbiome, anaerobes in the environment, diagnosis of anaerobes in clinical microbiology laboratories, molecular biology, genetics, pathogenesis, toxins and antibiotic susceptibility of anaerobic bacteria.