Association between Serum Lactate Dehydrogenase Level and 30-day Mortality in Patients with Intracranial Hemorrhage with Acute Leukemia in the Induction Phase: A Cohort Study

IF 1.2 Q4 GENETICS & HEREDITY
Jia-Yuan Zhang, Zhang-Song Yan, Xiu-Juan Sun, Yong-Ze Liu, Yan-Ke Yin, Ming-Huan Su, Qiu-Ling Li, Ying-Chang Mi, Da-Peng Li
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Abstract

Objectives  This study aimed to identify the association between lactate dehydrogenase (LDH) levels and 30-day mortality in patients with intracranial hemorrhage (ICH) with acute leukemia during the induction phase. Methods  This cohort study included patients with acute leukemia with ICH during induction. We evaluated serum LDH levels upon admission. Multivariable Cox regression analyzed the LDH 30-day mortality association. Interaction and stratified analyses based on factors like age, sex, albumin, white blood cell count, hemoglobin level, and platelet count were conducted. Results  We selected 91 patients diagnosed with acute leukemia and ICH. The overall 30-day mortality rate was 61.5%, with 56 of the 91 patients succumbing. Among those with LDH levels ≥ 570 U/L, the mortality rate was 74.4% (32 out of 43), which was higher than the 50% mortality rate of the LDH < 570 U/L group (24 out of 48) ( p  = 0.017). In our multivariate regression models, the hazard ratios and their corresponding 95% confidence intervals for Log2 and twice the upper limit of normal LDH were 1.27 (1.01, 1.58) and 2.2 (1.05, 4.58), respectively. Interaction analysis revealed no significant interactive effect on the relationship between LDH levels and 30-day mortality. Conclusions  Serum LDH level was associated with 30-day mortality, especially in patients with LDH ≥ 570 U/L.
急性白血病颅内出血诱导期患者血清乳酸脱氢酶水平与 30 天死亡率的关系:队列研究
目的 本研究旨在确定急性白血病诱导期颅内出血(ICH)患者的乳酸脱氢酶(LDH)水平与 30 天死亡率之间的关系。方法 该队列研究纳入了在诱导期发生 ICH 的急性白血病患者。我们评估了患者入院时的血清 LDH 水平。多变量 Cox 回归分析了 LDH 与 30 天死亡率的关系。根据年龄、性别、白蛋白、白细胞计数、血红蛋白水平和血小板计数等因素进行了交互分析和分层分析。结果 我们选择了 91 名确诊为急性白血病和 ICH 的患者。91 名患者中有 56 人死亡,30 天内的总死亡率为 61.5%。在 LDH 水平≥ 570 U/L的患者中,死亡率为 74.4%(43 例中有 32 例),高于 LDH < 570 U/L组 50%的死亡率(48 例中有 24 例)(P = 0.017)。在我们的多变量回归模型中,LDH 的 Log2 和正常上限的两倍的危险比及其相应的 95% 置信区间分别为 1.27 (1.01, 1.58) 和 2.2 (1.05, 4.58)。交互分析显示,LDH 水平与 30 天死亡率之间没有明显的交互影响。结论 血清 LDH 水平与 30 天死亡率相关,尤其是 LDH ≥ 570 U/L的患者。
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来源期刊
Global Medical Genetics
Global Medical Genetics GENETICS & HEREDITY-
自引率
11.80%
发文量
30
审稿时长
14 weeks
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