Ablation of the epicardial substrate in patients with long-QT syndrome at risk of sudden death

IF 1.7 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Carlo Pappone, A. Boccellino, G. Ciconte, Luigi Anastasia
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引用次数: 0

Abstract

Sudden cardiac death remains a critical public health concern globally, affecting millions annually. Recent advances in cardiac arrhythmia mapping have demonstrated that the ventricular epicardial region has a critical arrhythmogenic role in some inherited cardiogenetic diseases. Among these, long-QT syndrome (LQTS) exposes patients to the risk of life-threatening arrhythmic events. Despite advancements, there is a need for more effective therapeutic strategies. A recent study has uncovered a noteworthy connection between LQTS and epicardial structural abnormalities, challenging the traditional view of LQTS as purely an electrical disorder. High-density mapping revealed electroanatomic abnormalities in the right ventricular epicardium, presenting a potential target for catheter ablation, to finally suppress ventricular fibrillation recurrences in high-risk LQTS patients.
消融有猝死风险的长 QT 综合征患者的心外膜基质
心脏性猝死仍然是全球关注的一个重要公共卫生问题,每年影响数百万人。心律失常图谱绘制的最新进展表明,在一些遗传性心脏病中,心室外膜区域具有关键的致心律失常作用。其中,长 QT 综合征(LQTS)使患者面临危及生命的心律失常风险。尽管取得了进展,但仍需要更有效的治疗策略。最近的一项研究发现,LQTS 与心外膜结构异常之间存在值得注意的联系,这挑战了将 LQTS 视为纯粹心电紊乱的传统观点。高密度绘图显示了右心室心外膜的电解剖异常,为导管消融提供了潜在目标,最终抑制了高风险 LQTS 患者的室颤复发。
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来源期刊
European Heart Journal Supplements
European Heart Journal Supplements 医学-心血管系统
CiteScore
3.00
自引率
0.00%
发文量
575
审稿时长
12 months
期刊介绍: The European Heart Journal Supplements (EHJs) is a long standing member of the ESC Journal Family that serves as a publication medium for supplemental issues of the flagship European Heart Journal. Traditionally EHJs published a broad range of articles from symposia to special issues on specific topics of interest. The Editor-in-Chief, Professor Roberto Ferrari, together with his team of eminent Associate Editors: Professor Francisco Fernández-Avilés, Professors Jeroen Bax, Michael Böhm, Frank Ruschitzka, and Thomas Lüscher from the European Heart Journal, has implemented a change of focus for the journal. This entirely refreshed version of the European Heart Journal Supplements now bears the subtitle the Heart of the Matter to give recognition to the focus the journal now has. The EHJs – the Heart of the Matter intends to offer a dedicated, scientific space for the ESC, Institutions, National and Affiliate Societies, Associations, Working Groups and Councils to disseminate their important successes globally.
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