Recent alcohol intake impacts microbiota in adult burn patients

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol Pub Date : 2024-04-10 DOI:10.1016/j.alcohol.2024.04.003

Andrew J. Hoisington , Kevin Choy , Shanawaj Khair , Kiran U. Dyamenahalli , Kevin M. Najarro , Arek J. Wiktor , Daniel N. Frank , Ellen L. Burnham , Rachel H. McMahan , Elizabeth J. Kovacs

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引用次数: 0

Abstract

Alcohol use is associated with an increased incidence of negative health outcomes in burn patients due to biological mechanisms that include a dysregulated inflammatory response and increased intestinal permeability. This study used phosphatidylethanol (PEth) in blood, a direct biomarker of recent alcohol use, to investigate associations between a recent history of alcohol use and the fecal microbiota, short chain fatty acids, and inflammatory markers in the first week after a burn injury for nineteen participants. Burn patients were grouped according to PEth levels of low or high and differences in the overall fecal microbial community were observed between these cohorts. Two genera that contributed to the differences and had higher relative abundance in the low PEth burn patient group were Akkermansia, a mucin degrading bacteria that improves intestinal barrier function, and Bacteroides, a potentially anti-inflammatory bacteria. There was no statistically significant difference between levels of short chain fatty acids or intestinal permeability across the two groups. To our knowledge, this study represents the first report to evaluate the effects of burn injury and recent alcohol use on early post burn microbiota dysbiosis, inflammatory response, and levels of short chain fatty acids. Future studies in this field are warranted to better understand the factors associated with negative health outcomes and develop interventional trials.

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近期摄入的酒精会影响成年烧伤患者的微生物群。

由于炎症反应失调和肠道渗透性增加等生物机制，饮酒与烧伤患者不良健康后果发生率的增加有关。本研究使用血液中的磷脂酰乙醇（PEth）--近期饮酒的直接生物标志物--来调查 19 名参与者近期饮酒史与烧伤后第一周粪便微生物群、短链脂肪酸和炎症标志物之间的关系。烧伤患者根据 PEth 水平的高低分组，并观察到这些组群之间整体粪便微生物群落的差异。在低 PEth 烧伤患者组中，有两个菌属造成了差异，而且相对丰度较高，它们是 Akkermansia 和 Bacteroides，前者是一种可改善肠道屏障功能的粘蛋白降解菌，后者则是一种潜在的抗炎细菌。两组患者的短链脂肪酸水平或肠道通透性在统计学上没有明显差异。据我们所知，这项研究是第一份评估烧伤和近期饮酒对烧伤后早期微生物群失调、炎症反应和短链脂肪酸水平影响的报告。今后有必要在这一领域开展研究，以更好地了解与负面健康结果相关的因素，并开展干预试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.