Presencia de puntos hiperreflectivos subfoveales como biomarcador pronóstico anatómico y funcional en agujero macular

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2024-06-01 DOI:10.1016/j.oftal.2024.03.008

D. Rueda-Latorre , J.A. Sosa-Lockward , N. Abreu-Arbaje

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引用次数: 0

Abstract

Objective

To evaluate the presence of subfoveal hyperreflective dots (SfHD) using optical coherence tomography (OCT) in macular holes (MH) and establish whether there is a relationship with postoperative anatomical and functional outcomes.

Methods

An observational cross-sectional study was conducted at the Dr. Elías Santana Hospital. Sixty-eight eyes of 67 patients with a tomographic diagnosis of full-thickness MH who underwent pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling were included. Preoperative and postoperative measurements were obtained using radial macular scans and HD raster scans with Optovue and Cirrus 5000 (Zeiss) OCT machines. The main outcome measures were anatomical closure by OCT and functional outcome through best-corrected visual acuity (BCVA).

Results

The anatomical closure rate in our study was 63%. MHs that failed to achieve anatomical closure exhibited a higher number of hyperreflective dots and worse postoperative BCVA. A statistically significant association was found between exposed retinal pigment epithelium (RPE) in microns and the number of SfHD (p = 0.001).

Conclusion

SfHD is a common tomographic finding in MH, and the presence of a higher number of these points is associated with poorer anatomical and functional outcomes. This imaging finding is a potential prognostic biomarker in this pathology.

查看原文本刊更多论文

眼底高反射斑是黄斑孔的解剖和功能性预后生物标记。

方法在埃利亚斯-桑塔纳博士医院进行了一项横断面观察研究。研究纳入了67名经断层扫描诊断为全厚MH的患者的68只眼睛，这些患者接受了玻璃体旁切除术（PPV）和内限膜（ILM）剥离术。使用 Optovue 和 Cirrus 5000（蔡司）OCT 机进行黄斑径向扫描和高清光栅扫描，获得术前和术后测量结果。主要结果指标是通过 OCT 观察解剖闭合情况和通过最佳矫正视力（BCVA）观察功能结果。未能达到解剖闭合的 MHs 表现出更多的高反射点，术后 BCVA 更差。研究发现，暴露的视网膜色素上皮（RPE）微米数与 SfHD 的数量有统计学意义（p = 0.001）。这一成像发现是该病症的潜在预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archivos De La Sociedad Espanola De Oftalmologia Medicine-Ophthalmology

CiteScore

1.20

自引率

0.00%

发文量

109

审稿时长

78 days

期刊介绍： La revista Archivos de la Sociedad Española de Oftalmología, editada mensualmente por la propia Sociedad, tiene como objetivo publicar trabajos de investigación básica y clínica como artículos originales; casos clínicos, innovaciones técnicas y correlaciones clinicopatológicas en forma de comunicaciones cortas; editoriales; revisiones; cartas al editor; comentarios de libros; información de eventos; noticias personales y anuncios comerciales, así como trabajos de temas históricos y motivos inconográficos relacionados con la Oftalmología. El título abreviado es Arch Soc Esp Oftalmol, y debe ser utilizado en bibliografías, notas a pie de página y referencias bibliográficas.