Clinical efficacy of modern emollients in atopic dermatitis: case reports

Abstract

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, characterized by itching, chronic recurrent course, and in most cases is associated with respiratory allergies – allergic rhinitis and asthma. The incidence of AD varies from 15 to 30% or more among children and from 2 to 14% among adults in different countries. The pathophysiological mechanisms of AD are based on a genetic predisposition to allergies, immune dysregulation, and the influence of environmental factors. Recent studies have shown that a key feature of AD is a barrier defects in compromised skin which leads to increased permeability and penetration of environmental factors (e.g., microbes, allergens) and finally to allergen sensitization and to the development of specific allergic inflammation in the target organ – the skin. The article presents a series of clinical cases of moderate and severe AD, demonstrated an integrated approach to the treatment and selection of emollients, considering the phenotypic features of AD.