Clinical implications of persistent joint pain after gout flare

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-01 DOI:10.1016/j.reuma.2024.03.002

Wei Liu , Peng Dong , Chunyan Li , Wen Guo , Kaiping Zhao , Siliang Man , Liang Zhang , Husheng Wu , Hui Song

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引用次数: 0

Abstract

Objectives

A subset of gout patients developed persistent joint pain after flares. Analysis of this clinical phenomenon may shed further light on the factors related to worsening gout and even provide clues to its pathogenesis.

Methods

We analyzed the clinical, laboratory, and ultrasound data of gout patients to explore the associations of these data with persistent joint pain after gout flares.

Results

A total of 1029 gout patients were included: 182 (17.7%) patients with persistent joint pain and 847 (82.3%) patients with nonpersistent joint pain. Patients with persistent joint pain had more total involved joints, more gout flares in the past year, and more joints with simultaneous gout flares (P < 0.01). Among the ultrasound-detected lesions, patients with persistent joint pain had a higher incidence of tophus (36.4% vs. 21.1%) and bone erosion (18.6% vs. 8.6%) (P < 0.05). Higher UA and lower TBil were found in patients with persistent joint pain (P < 0.001). Hypertension (54.9% vs. 38.7%) and metabolic syndrome (58.8% vs. 46.4%) were both more frequent in patients with persistent joint pain (P < 0.05). TBil was negatively correlated with the incidence of persistent joint pain (P < 0.001, r = −0.190), UA values (P < 0.001, r = −0.125), and metabolic syndrome scores (P < 0.001, r = −0.192). A correlation curve was fitted using LOESS (locally weighted region).

Conclusion

Persistent joint pain after gout flares is a marker of increased disease burden in gout. The significance of the level of total bilirubin for the exacerbation of gout deserves further study.

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痛风发作后持续性关节疼痛的临床意义

目的一部分痛风患者在病情发作后会出现持续性关节疼痛。方法我们分析了痛风患者的临床、实验室和超声波数据，探讨了这些数据与痛风发作后持续性关节疼痛的关联：其中182人（17.7%）患有持续性关节疼痛，847人（82.3%）患有非持续性关节疼痛。持续性关节疼痛患者受累关节总数较多、过去一年痛风发作次数较多、同时痛风发作的关节较多（P< 0.01）。在超声检测到的病变中，持续性关节疼痛患者的脓肿（36.4% 对 21.1%）和骨侵蚀（18.6% 对 8.6%）发生率更高（P < 0.05）。持续性关节疼痛患者的尿酸值较高，TBil较低（P < 0.001）。高血压（54.9% 对 38.7%）和代谢综合征（58.8% 对 46.4%）在持续性关节疼痛患者中更为常见（P < 0.05）。TBil 与持续性关节疼痛发生率（P < 0.001，r = -0.190）、UA 值（P < 0.001，r = -0.125）和代谢综合征评分（P < 0.001，r = -0.192）呈负相关。结论痛风发作后持续的关节疼痛是痛风疾病负担加重的标志。总胆红素水平对痛风加重的意义值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.