Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases

IF 15.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2024-04-21 DOI:10.1016/j.addr.2024.115323

Pengxuan Zhao , Tiantian Wu , Yu Tian , Jia You , Xinwu Cui

引用次数: 0

Abstract

With the aging population on the rise, neurodegenerative disorders have taken center stage as a significant health concern. The blood–brain barrier (BBB) plays an important role to maintain the stability of central nervous system, yet it poses a formidable obstacle to delivering drugs for neurodegenerative disease therapy. Various methods have been devised to confront this challenge, each carrying its own set of limitations. One particularly promising noninvasive approach involves the utilization of focused ultrasound (FUS) combined with contrast agents—microbubbles (MBs) to achieve transient and reversible BBB opening. This review provides a comprehensive exploration of the fundamental mechanisms behind FUS/MBs-mediated BBB opening and spotlights recent breakthroughs in its application for neurodegenerative diseases. Furthermore, it addresses the current challenges and presents future perspectives in this field.

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聚焦超声诱导血脑屏障开放在神经退行性疾病临床应用方面的最新进展。

随着人口老龄化的加剧，神经退行性疾病已成为人们关注的主要健康问题。血脑屏障（BBB）在维持中枢神经系统的稳定性方面发挥着重要作用，但它却对神经退行性疾病的药物输送构成了巨大障碍。为应对这一挑战，人们设计了各种方法，但每种方法都有其自身的局限性。一种特别有前景的非侵入性方法是利用聚焦超声（FUS）结合造影剂--微气泡（MBs）来实现瞬时和可逆的 BBB 开放。本综述全面探讨了 FUS/MBs 介导的 BBB 开放背后的基本机制，并重点介绍了其在神经退行性疾病应用方面的最新突破。此外，它还探讨了这一领域当前面临的挑战，并提出了未来的展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.

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