GREEN ANTI-BIOFILM AGENTS: A MINI-REVIEW

Abstract

Microbial biolm is the polymeric matrix formed by coordinated assembly of species of similar or different microorganisms. The bacteria in form of biolms are more resistant to drugs than compared to their planktonic counterparts, hence making it difcult to deal with biolm-associated nosocomial and medical device infections. Around $11 billion is annual expenditure reported to be employed in healthcare to deal with biolm infections but the success rates are very low. Studies on natural anti-biolm agents from the last two decades notably demonstrated their biolm modulation properties. Therefore, present state of affairs demands active pursual for non-toxic natural anti-biolm agents. In this mini-review article, we summarize green anti-biolm agents: antimicrobial peptides (AMPs), phytochemicals, biosurfactants, nanoparticles, and weak organic acids (WOA) with a brief note on their mode of action.