Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Safa Sami, Naser Shaalan
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引用次数: 0

Abstract

In the present study, a novel ligand (L) made of 2-hydroxynaphthaldehyde and 3-hydrazone-1,3-dihydro-indole-2-one(3-[(3-hydroxynaphthalen-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one). The ligand was characterized by FTIR, UV-vis, mass, 1H-NMR, 13C-NMR, and CHN elemental analysis. New complexes of this ligand were created by treating methanol and a drop of DMF solution of the produced ligand with the hydrated metal salts of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) in a molar ratio of 2:1 (L:M). As a result, complexes have been emerged and identified FTIR, UV-vis, C.H.N., chloride-containing, molar conductance, magnetic susceptibility, and atomic absorption. The characterization result for each complex indicated complexes with octahedral coordination geometry and tridentates with metal to ligand ratios of 1:2. The biological activities of the new compounds were examined against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) giving an acceptable inhibition efficiency.
基于 3-[(3-羟基萘-2-基-亚乙基)-肼基]-1,3-二氢吲哚-2-酮的新型金属离子配合物的合成、结构和生物活性研究
本研究中的新型配体(L)由 2-羟基萘醛和 3-腙-1,3-二氢-吲哚-2-酮(3-[(3-羟基萘-2-基-亚乙基)-腙]-1,3-二氢-吲哚-2-酮)组成。通过傅立叶变换红外光谱(FTIR)、紫外可见光谱(UV-vis)、质量、1H-NMR、13C-NMR 和 CHN 元素分析对配体进行了表征。通过将生成配体的甲醇和一滴 DMF 溶液与 Mn(II)、Co(II)、Ni(II)、Cu(II) 和 Zn(II) 的水合金属盐以 2:1 (L:M)的摩尔比进行处理,生成了该配体的新配合物。因此,络合物已经出现,并通过傅立叶变换红外光谱(FTIR)、紫外可见光谱(UV-vis)、C.H.N.光谱(C.H.N.)、氯离子含量、摩尔电导、磁感应强度和原子吸收进行了鉴定。每个配合物的表征结果表明,配合物都具有八面体配位几何和三叉配位,金属与配体的比例为 1:2。研究人员考察了新化合物对革兰氏阴性菌(大肠杆菌)和革兰氏阳性菌(金黄色葡萄球菌)的生物活性,结果表明其抑制效率是可以接受的。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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