Amplification of positivity for depression and anxiety: Neural prediction of treatment response

IF 4.2 2区心理学 Q1 PSYCHOLOGY, CLINICAL

Behaviour Research and Therapy Pub Date : 2024-04-23 DOI:10.1016/j.brat.2024.104545

Maria Kryza-Lacombe , Isabella Spaulding , Cheuk King Ku , Nana Pearson , Murray B. Stein , Charles T. Taylor

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引用次数: 0

Abstract

Psychosocial treatments targeting the positive valence system (PVS) in depression and anxiety demonstrate efficacy in enhancing positive affect (PA), but response to treatment varies. We examined whether individual differences in neural activation to positive and negative valence incentive cues underlies differences in benefitting from a PVS-targeted treatment. Individuals with clinically elevated depression and/or anxiety (N = 88, ages 18 to 55) participated in one of two randomized, waitlist-controlled trials of Amplification of Positivity (AMP; NCT02330627, NCT03196544), a cognitive and behavioral intervention targeting the PVS. Participants completed a monetary incentive delay (MID) task during fMRI acquisition at baseline measuring neural activation to the possibility of gaining or losing money. Change in PA from before to after treatment was assessed using the Positive and Negative Affect Schedule. No significant associations were observed between baseline neural activation during gain anticipation and AMP-related changes in PA in regions of interest (striatum and insula) or whole-brain analyses. However, higher baseline striatal and insula activation during loss anticipation was associated with greater increases in PA post-AMP. This study provides preliminary evidence suggesting neural reactivity to negative valence cues may inform who stands to benefit most from treatments targeting the PVS.

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积极情绪对抑郁和焦虑的放大作用：治疗反应的神经预测

针对抑郁症和焦虑症患者积极情绪系统（PVS）的社会心理治疗在增强积极情绪（PA）方面具有疗效，但治疗反应却各不相同。我们研究了神经激活对积极和消极情绪激励线索的个体差异是否是从以积极情绪系统为目标的治疗中获益的差异的基础。抑郁症和/或焦虑症患者（88 人，18 至 55 岁）参加了 "积极性放大"（AMP；NCT02330627、NCT03196544）两项随机、候选对照试验中的一项。参试者在基线时的 fMRI 采集过程中完成一项货币激励延迟（MID）任务，测量神经对获得或失去金钱的可能性的激活情况。使用积极和消极情绪表评估治疗前和治疗后 PA 的变化。在相关区域（纹状体和脑岛）或全脑分析中，未观察到收益预期期间的基线神经激活与 AMP 相关 PA 变化之间存在明显关联。然而，损失预期时纹状体和脑岛的基线激活较高与AMP后PA的增加有关。这项研究提供的初步证据表明，神经对负面情绪线索的反应可能会告知哪些人从针对PVS的治疗中获益最多。

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来源期刊

Behaviour Research and Therapy PSYCHOLOGY, CLINICAL-

CiteScore

7.50

自引率

7.30%

发文量

148

期刊介绍： The major focus of Behaviour Research and Therapy is an experimental psychopathology approach to understanding emotional and behavioral disorders and their prevention and treatment, using cognitive, behavioral, and psychophysiological (including neural) methods and models. This includes laboratory-based experimental studies with healthy, at risk and subclinical individuals that inform clinical application as well as studies with clinically severe samples. The following types of submissions are encouraged: theoretical reviews of mechanisms that contribute to psychopathology and that offer new treatment targets; tests of novel, mechanistically focused psychological interventions, especially ones that include theory-driven or experimentally-derived predictors, moderators and mediators; and innovations in dissemination and implementation of evidence-based practices into clinical practice in psychology and associated fields, especially those that target underlying mechanisms or focus on novel approaches to treatment delivery. In addition to traditional psychological disorders, the scope of the journal includes behavioural medicine (e.g., chronic pain). The journal will not consider manuscripts dealing primarily with measurement, psychometric analyses, and personality assessment.