Dahee Shim , Yeeun Bak , Han-Gyu Choi , Seunghyun Lee , Sang Chul Park
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引用次数: 0
Abstract
Panax species include Panax ginseng Meyer, Panax quinquefolium L., Panax notoginseng, Panax japonicum, Panax trifolium, and Panax pseudoginseng, which contain bioactive components (BCs) such as ginsenosides and polysaccharides. Recently, growing evidence has revealed the pharmacological effects of Panax species and their BCs on allergic airway diseases (AADs), including allergic asthma (AA) and allergic rhinitis (AR). AADs are characterized by damaged epithelium, sustained acquired immune responses with enforced Th2 responses, allergen-specific IgE production, and enhanced production of histamine and leukotrienes by activated mast cells and basophils. In this review, we summarize how Panax species and their BCs modulate acquired immune responses involving interactions between dendritic cells and T cells, reduce the pro-inflammatory responses of epithelial cells, and reduce allergenic responses from basophils and mast cells in vitro. In addition, we highlight the current understanding of the alleviative effects of Panax species and their BCs against AA and AR in vivo. Moreover, we discuss the unmet needs of research and considerations for the treatment of patients to provide basic scientific knowledge for the treatment of AADs using Panax species and their BCs.
三七品种包括人参、五加参、三七、日本三七、三叶草和三七,其中含有人参皂甙和多糖等生物活性成分(BCs)。最近,越来越多的证据表明,三七及其生物活性成分对过敏性气道疾病(AADs),包括过敏性哮喘(AA)和过敏性鼻炎(AR)有药理作用。过敏性气道疾病的特点是上皮受损、持续的获得性免疫反应(Th2 反应增强)、过敏原特异性 IgE 的产生以及活化的肥大细胞和嗜碱性粒细胞产生的组胺和白三烯增多。在这篇综述中,我们总结了三七及其生物碱如何调节涉及树突状细胞和 T 细胞之间相互作用的获得性免疫反应、降低上皮细胞的促炎反应以及减少嗜碱性粒细胞和肥大细胞在体外产生的过敏原反应。此外,我们还强调了目前对三七及其生物碱在体内对 AA 和 AR 的缓解作用的理解。此外,我们还讨论了尚未满足的研究需求和治疗患者的注意事项,为使用三七及其生物碱治疗 AADs 提供基础科学知识。
期刊介绍:
Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research.
JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports.
JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.