Ultrasound-Enabled Nanomedicine for Tumor Theranostics

IF 10.1 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering Pub Date : 2025-03-01 DOI:10.1016/j.eng.2024.01.030

Kairui Liu , Boyuan Jing , Jun Kang , Lei Han , Jin Chang

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Abstract

Ultrasound-enabled nanomedicine leverages ultrasound to amplify the capabilities of engineered nanosystems, paving the way for innovative diagnostic and therapeutic breakthroughs in conventional nanomedicine. As a burgeoning discipline, past overviews have sometimes offered a fragmented perspective, lacking a comprehensive view. This review presents a systematic exploration of the latest advancements in ultrasound-enabled nanomedicine, with a particular emphasis on oncology. Covered topics include molecular imaging of tumors, separation of tumor markers, penetration through physiological barriers, perforation of cell membranes, targeted drug release and activation strategies, and an array of sonotherapies for oncological treatments. We delve into the research framework of each topic, the foundational design of the nanosystems, and their associated ultrasound activation mechanisms. Moreover, we highlight recent pivotal research aimed at deepening the reader's understanding of this intricate domain. This review underscores the integration of design and foundational theories within ultrasound-enabled nanomedicine, aspiring to ignite advanced theoretical insights and introduce innovative design paradigms. In conclusion, we outline current challenges and prospective research directions. An enhanced focus on these areas will expedite the advancement of ultrasound-enabled nanomedicine.

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用于肿瘤血清疗法的超声纳米医学

超声波纳米医学利用超声波来增强工程纳米系统的能力，为传统纳米医学的创新诊断和治疗突破铺平了道路。作为一门新兴的学科，过去的概述有时提供了一个碎片化的视角，缺乏一个全面的观点。这篇综述介绍了超声纳米医学的最新进展的系统探索，特别强调肿瘤学。涵盖的主题包括肿瘤的分子成像，肿瘤标记物的分离，穿透生理屏障，细胞膜穿孔，靶向药物释放和激活策略，以及肿瘤治疗的一系列超声疗法。我们深入研究了每个主题的研究框架，纳米系统的基本设计，以及它们相关的超声激活机制。此外，我们强调了最近的关键研究，旨在加深读者对这一复杂领域的理解。这篇综述强调了超声纳米医学中设计和基础理论的整合，渴望点燃先进的理论见解和引入创新的设计范式。最后，我们概述了当前的挑战和未来的研究方向。加强对这些领域的关注将加快超声纳米医学的发展。

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来源期刊

Engineering Environmental Science-Environmental Engineering

自引率

1.60%

发文量

335

审稿时长

35 days

期刊介绍： Engineering, an international open-access journal initiated by the Chinese Academy of Engineering (CAE) in 2015, serves as a distinguished platform for disseminating cutting-edge advancements in engineering R&D, sharing major research outputs, and highlighting key achievements worldwide. The journal's objectives encompass reporting progress in engineering science, fostering discussions on hot topics, addressing areas of interest, challenges, and prospects in engineering development, while considering human and environmental well-being and ethics in engineering. It aims to inspire breakthroughs and innovations with profound economic and social significance, propelling them to advanced international standards and transforming them into a new productive force. Ultimately, this endeavor seeks to bring about positive changes globally, benefit humanity, and shape a new future.