Causal Relationship Between Endometriosis and Pelvic Inflammatory Diseases: Mendelian Randomization Study

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Kang Liu, Xiaochun Liu, Tao Cao, Xianmei Cui, Pengyu Sun, Liang Zhang, Xiaoqin Wu
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引用次数: 0

Abstract

Objective: This study explores the causal relationship between endometriosis and pelvic inflammatory diseases (PID). Methods: The study utilized genome-wide association study (GWAS) datasets for endometriosis (“finn-b-N14_ENDOMETRIOSIS“) and PID (”finn-b-N14_OTHFEMPELINF”). Subsequently, two-sample Mendelian randomization (MR) analyses were conducted using inverse variance weighting (IVW), Egger regression (MR-Egger), and weighted median (WM) methods. Heterogeneity was evaluated using Cochran’s Q test, and in case of detected outliers, they were removed for re-evaluation of MR causality. Results: From the endometriosis GWAS dataset, 33 single nucleotide polymorphisms (SNPs) were selected as instrumental variables. All three methods, IVW (OR = 1.39, P < 1×10 −8 ), MR-Egger (OR = 1.41, P = 0.003), and WM (OR = 1.37, P = 1.16×10 −5 ) confirmed a causal relationship between endometriosis and PID. The association between endometriosis and pelvic inflammation remained unaffected by the exclusion of individual SNPs. Lastly, Cochran’s Q test and funnel plots showed no evidence of SNP asymmetry. Conclusion: The results of the MR analysis support a potential causal relationship between endometriosis and an increased risk of PID.
子宫内膜异位症与盆腔炎之间的因果关系:孟德尔随机研究
研究目的本研究探讨子宫内膜异位症与盆腔炎(PID)之间的因果关系。研究方法研究利用子宫内膜异位症("finn-b-N14_ENDOMETRIOSIS")和盆腔炎("finn-b-N14_OTHFEMPELINF")的全基因组关联研究(GWAS)数据集。随后,使用反方差加权法(IVW)、艾格回归法(MR-Egger)和加权中位数法(WM)进行了双样本孟德尔随机化(MR)分析。使用 Cochran's Q 检验评估异质性,如果发现异常值,则将其剔除,以重新评估 MR 因果关系。结果从子宫内膜异位症 GWAS 数据集中选取了 33 个单核苷酸多态性(SNPs)作为工具变量。所有三种方法:IVW(OR = 1.39,P < 1×10 -8)、MR-Egger(OR = 1.41,P = 0.003)和 WM(OR = 1.37,P = 1.16×10 -5)都证实了子宫内膜异位症与 PID 之间的因果关系。排除单个 SNP 后,子宫内膜异位症与盆腔炎之间的关系仍未受到影响。最后,Cochran's Q 检验和漏斗图未显示 SNP 不对称的证据。结论磁共振分析的结果支持子宫内膜异位症与 PID 风险增加之间存在潜在的因果关系。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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