{"title":"Advances in the treatment of Philadelphia chromosome negative acute lymphoblastic leukemia","authors":"Madelyn Burkart , Shira Dinner","doi":"10.1016/j.blre.2024.101208","DOIUrl":null,"url":null,"abstract":"<div><p>There have been major paradigm shifts in the treatment of Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL) in the last decade with the introduction of new immunotherapies and targeted agents, adoption of pediatric-type chemotherapy protocols in younger adults as well as chemotherapy light approaches in older adults and the incorporation of measurable residual disease (MRD) testing to inform clinical decision making. With this, treatment outcomes in adult Ph- ALL have improved across all age groups. However, a subset of patients will still develop relapsed disease, which can be challenging to treat and associated with poor outcomes. Here we review the treatment of Ph- ALL in both younger and older adults, including the latest advancements and future directions.</p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":"66 ","pages":"Article 101208"},"PeriodicalIF":6.9000,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0268960X24000419","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
There have been major paradigm shifts in the treatment of Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL) in the last decade with the introduction of new immunotherapies and targeted agents, adoption of pediatric-type chemotherapy protocols in younger adults as well as chemotherapy light approaches in older adults and the incorporation of measurable residual disease (MRD) testing to inform clinical decision making. With this, treatment outcomes in adult Ph- ALL have improved across all age groups. However, a subset of patients will still develop relapsed disease, which can be challenging to treat and associated with poor outcomes. Here we review the treatment of Ph- ALL in both younger and older adults, including the latest advancements and future directions.
在过去十年中，随着新型免疫疗法和靶向药物的引入、在年轻成人中采用儿科型化疗方案以及在老年成人中采用轻化疗方法，并将可测量残留疾病（MRD）检测纳入临床决策，费城染色体阴性（Ph-）急性淋巴细胞白血病（ALL）的治疗模式发生了重大转变。因此，所有年龄组的成人非小细胞肺癌治疗效果都有所改善。然而，仍有一部分患者会出现复发，这不仅治疗难度大，而且疗效不佳。在此，我们回顾了年轻和年长成人 ALL Ph 细胞的治疗，包括最新进展和未来方向。
期刊介绍：
Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.
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