Surgical Antimicrobial Prophylaxis Compliance in Turkey: Data from the Prospective, Observational, Multicenter Survey Including 7,978 Surgical Patients.
Semiha Çelik Ekinci, E. Yenilmez, Gülfem Akengin Öcal, M. Ç. Sönmezer, Arzu Tarakçı, Cemanur Aygün, Damla Akdağ, D. Seyman, Cansu Aşık, E. Zerdali, Fatma Yılmaz Karadağ, Şafak Kaya, Mehmet Çelik, Şeyma Çifci, İlknur Esen Yıldız, Fatma Çölkesen, Fethiye Akgül, Özlem Aldemir, Merve Bozdağ, Deniz Özer, L. Hızmalı, Esra Canbolat Ünlü, Deniz Gür Altunay, Ahmet Şahin, Gülten Ünlü, Ayşe Eda Gençalioğlu, Sema Tekin Şahin, Yeliz Özdemir, Sibel Ünlü, Sarp Singil, Jale Altıntaş, Sinem Akkaya Işık, Özlem Gül, N. Tuna, Sümeyra Şimşek, M. Özgüler, Pınar Elbir Kılıç, M. E. Işık, Ayşe Karakuş, Kazım Kıratlı, Ahmet Cem Yardımcı, Serkan Volkan, Yıldız Olçar, Yasemin Çakır, Nermin Özer Yılmaz, Serhat Karaayvaz, A. Batırel, Z. C. Duran, Huseyin Kemal Raşa, Şükran Köse
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引用次数: 0
Abstract
Background: Surgical antimicrobial prophylaxis (SAP) is the peri-operative administration of antimicrobial agents. Compliance rates vary worldwide from 15% to 84.3%, with studies in Turkey not exceeding 35%. The aim of this multicenter study was to determine the rate of appropriate antibiotic class, timing, and duration as well as discharge prescriptions in Turkey. Thus, we aimed to determine the rate of full compliance with SAP procedures in our country Patients and Methods: This multicenter, prospective, observational, descriptive study was conducted in 47 hospitals from 28 provinces in seven different regions of Turkey. Patients over 18 years of age in all surgical units between June 6, 2022, and June 10, 2022, were included in the study. Results: Of the 7,978 patients included in the study, 332 were excluded from further analyses because of pre-existing infection, and SAP compliance analyses were performed on the remaining 7,646 cases. The antibiotic most commonly used for SAP was cefazolin (n = 4,701; 61.5%), followed by third-generation cephalosporins (n = 596; 7.8%). The most common time to start SAP was within 30 minutes before surgery (n = 2,252; 32.5%), followed by 30 to 60 minutes before surgery (n = 1,638; 23.6%). Surgical antimicrobial prophylaxis duration was <24 hours in 3,516 (50.7%) patients and prolonged until discharge in 1,505 (21.7%) patients. Finally, the actual proportion of patients compliant with SAP was 19% (n = 1,452) after omitting 4,458 (58.3%) patients who were prescribed oral antibiotic agents at discharge as part of a prolonged SAP. Conclusions: Surgical antimicrobial prophylaxis compliance rates are still very low in Turkey. Prolonged duration of SAP and especially high rate of antibiotic prescription at discharge are the main reasons for non-compliance with SAP.
期刊介绍:
Surgical Infections provides comprehensive and authoritative information on the biology, prevention, and management of post-operative infections. Original articles cover the latest advancements, new therapeutic management strategies, and translational research that is being applied to improve clinical outcomes and successfully treat post-operative infections.
Surgical Infections coverage includes:
-Peritonitis and intra-abdominal infections-
Surgical site infections-
Pneumonia and other nosocomial infections-
Cellular and humoral immunity-
Biology of the host response-
Organ dysfunction syndromes-
Antibiotic use-
Resistant and opportunistic pathogens-
Epidemiology and prevention-
The operating room environment-
Diagnostic studies