Exposure to heavy metals, antioxidant status, and the interaction of single nucleotide polymorphisms in the genes CAT rs7943316, GSTP1 rs1695, as well as GSTM1 and GSTT1 genes, among workers in occupational settings

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-04-23 DOI:10.1016/j.etap.2024.104452

Sosan Andleeb Khan , Syed Muhammad Nurulain , Rashid Nazir Qureshi , Amina Zafar , Zarish Riaz , Aneela Shoukat , Zahid Muneer , Nazia Bibi , Saqlain Raza , Sabir Hussain , Syed Tahir Abbas Shah

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Abstract

Individuals working in diverse fields are consistently exposed to work-related pollutants that can impact their overall health. The current study investigated the presence of pollutants in seven different occupational groups and their impact on human health. Biochemical and genetic approaches were employed. Heavy metals were determined by ICP-MS technique. Oxidative stress biochemical markers and molecular analysis of the glutathione transferases gene SNPs (GSTT1, GSTM1, GSTP1), catalase (CAT, rs7943316), and superoxide dismutase (SOD, rs17880487) was carried out. The results revealed a significantly higher quantity of Cd among five occupational groups. Catalase, malonaldehyde, and glutathione was significantly dysregulated. Molecular analysis of the gene SNPs suggests a probable relationship between the antioxidants and the phenotypic expression of the CAT, GSTP1, GSTT1, and GSTM1 SNPs. It is concluded that chronic exposure to occupational contaminants like Cd affects human health through oxidative stress in association with some of their gene SNPs.

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职业环境中工人的重金属暴露、抗氧化状态以及 CAT rs7943316、GSTP1 rs1695、GSTM1 和 GSTT1 基因中单核苷酸多态性的相互作用。

在不同领域工作的人经常会接触到与工作有关的污染物，这些污染物会影响他们的整体健康。目前的研究调查了七个不同职业群体中存在的污染物及其对人体健康的影响。研究采用了生化和遗传方法。重金属采用 ICP-MS 技术进行测定。对氧化应激生化指标以及谷胱甘肽转移酶基因 SNPs（GSTT1、GSTM1、GSTP1）、过氧化氢酶（CAT，rs7943316）和超氧化物歧化酶（SOD，rs17880487）进行了分子分析。结果显示，五个职业组的镉含量明显较高。过氧化氢酶、丙二醛和谷胱甘肽明显失调。基因 SNPs 的分子分析表明，抗氧化剂与 CAT、GSTP1、GSTT1 和 GSTM1 SNPs 的表型表达之间可能存在关系。结论是，长期暴露于镉等职业污染物会通过氧化应激影响人体健康，这与某些基因 SNPs 有关。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.