Capsaicin Ameliorates Chemotherapy Response via Cancer Hallmarks Modulation: An Overview of its Synergic Potential

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2024-04-20 DOI:10.1016/j.hermed.2024.100882

R.F. Costa , F.C. Cadoná

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引用次数: 0

Abstract

Introduction

Cancer is a disease caused by genetic changes and disordered cell growth with high incidences over the years. Conventional treatments such as chemotherapy act on cells that are in constant cell division; however, frequently, they are not selective to cancer cells and can damage healthy cells. For this reason, side effects such as nausea, dizziness, hair loss, weight loss, and fatigue are reported by patients. Moreover, some cancers present resistance to chemotherapy treatment. Therefore, studies focusing on functional and natural products, especially those rich in bioactive compounds, such as capsaicin, could be used as chemotherapy adjuvant to improve treatment response and decrease side effects.

Methods

In this scenario, we conducted a review of 75 articles regarding the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation.

Results

In this scenario, we reviewed the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation. This natural bioactive molecule ameliorates the chemotherapy response by several cancer pathway regulations.

Conclusions

This review was able to show that capsaicin has a remarkable effect as an adjuvant to improve chemotherapy and reduce side effects.

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辣椒素通过调节癌症标志改善化疗反应：综述其协同潜力

导言癌症是一种由基因变化和细胞生长紊乱引起的疾病，多年来发病率居高不下。化疗等传统疗法作用于不断分裂的细胞，但往往对癌细胞没有选择性，反而会损害健康细胞。因此，患者会出现恶心、头晕、脱发、体重减轻和疲劳等副作用。此外，有些癌症对化疗具有抗药性。因此，研究重点应放在功能性天然产品上，尤其是那些富含生物活性化合物的产品，如辣椒素，可用作化疗辅助药物，以改善治疗反应并减少副作用。结果在本方案中，我们综述了辣椒素通过调节癌症标志物来改善抗癌活性和化疗反应的 75 篇文章。结论本综述表明，辣椒素作为一种辅助药物，在改善化疗和减少副作用方面具有显著效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.